Association between vitamin D level and community-acquired late-onset neonatal sepsis.

Introduction: The objective was to determine the relationship between mother and infant vitamin D levels and late onset sepsis.

Population And Methods: Infants born > 37 weeks of gestational age who were hospitalized with the diagnosis of late-onset sepsis were enrolled to this prospective case control study. VitaminD levels of the infants and their mothers in the study and a control group were compared.

Tigecycline therapy in pediatric patients with multidrug resistant bacteremia.

Introduction: Multidrug resistance among bacteria increases the need for new therapeutic options. Tigecycline is one candidate drug, due to property of a wider anti-bacterial spectrum to multi-drug resistant (MDR) pathogens. However, it has still not been approved for use in pediatric patients.

Enzyme Replacement Therapy in Hypophosphatasia.

Hypophosphatasia (HPP) is associated with significant morbidity and mortality in pediatric patients. The disease also imposes a high disease-burden in adult-onset HPP. Asfotase alfa (AA) is the first-in-class, bone-targeted, enzyme- replacement therapy designated to reverse the skeletal mineralisation defects in HPP.

Experience and Prognosis of Systemic Neonatal Thrombosis at a Level III NICU.

Objective: The objective of this article was to evaluate neonates diagnosed systemic thrombosis and their outcomes.

Methods: We retrospectively evaluated data of neonatal systemic thrombosis between January 2011 and December 2016.

Results: Among 4376 hospitalized, 30 neonates (0.

A Novel Homozygous Mutation in the KCNJ11 Gene of a Neonate with Congenital Hyperinsulinism and Successful Management with Sirolimus.

Congenital hyperinsulinism (CHI) is the most common cause of neonatal persistent hypoglycemia caused by mutations in nine known genes. Early diagnosis and treatment are important to prevent brain injury. The clinical presentation and response to pharmacological therapy may vary depending on the underlying pathology.

Effects of Two Different Exogenous Surfactant Preparations on Serial Peripheral Perfusion Index and Tissue Carbon Monoxide Measurements in Preterm Infants with Severe Respiratory Distress Syndrome.

Background: Administration of an exogenous surfactant may affect both ventilatory and hemodynamic parameters in preterm infants with respiratory distress syndrome (RDS). Peripheral perfusion may be expected to be influenced, and serial perfusion index (PI) values may show this effect. Noninvasive transcutaneous carbon monoxide (TCO) monitoring may show RDS severity, oxidative and inflammatory stress, and response to surfactant treatment.

Optimal Time of Tracheotomy in Infants: Still a Dilemma.

Objective. Infants with respiratory failure may require prolonged intubation. There is no consensus on the time of tracheotomy in neonates.

Both parents of neonatal intensive care unit patients are at risk of depression.

Postpartum depression is a serious disorder that can be seen not only in mothers but also in fathers; therefore, it negatively affects the whole family. Hospitalization in the neonatal intensive care unit (NICU) is a stress factor for the parents and contributes to depression. We aimed to detect the frequency of postpartum depression and the contributing risk factors in parents of NICU patients.

LY96, UPKIB mutations and TLR4, CD14, MBL polymorphisms in children with urinary tract infection.

Objective: To evaluate genetic variations of innate immune system such as mannose binding lectin (MBL), Toll like receptor 4 (TLR4), CD14, LY96 (MD2) and Uroplakin 1B (UPK1B) genes in children with recurrent urinary tract infection (UTI).

Methods: The study included 30 children with recurrent UTI and 30 healthy controls. Blood was drawn and analysed for genetic polymorphisms of MBL, TLR4 and CD14 genes by the PCR-RFLP method.