Publications by authors named "Denison S Ryan"
Article Synopsis
- A study evaluated the participation rates of the Kaiser Permanente Side Effect Monitor (KPSEM), a self-reporting system for vaccine side effects, among patients receiving COVID-19 vaccinations from April 2021 to July 2023.
- Out of over 2 million vaccinated patients, only about 8% participated, with significant variations based on age and race; younger parents had the lowest rates, while older adults participated the most.
- The findings indicate that socio-economic factors influenced participation, as individuals in lower deprivation areas and certain racial groups were less likely to engage with the system.
Context: Primary hyperparathyroidism (PHPT) has initially been implicated in adverse maternal and neonatal outcomes, while subsequent population studies have failed to show an association.
Objective: To compare maternal, pregnancy, and neonatal outcomes in patients with and without PHPT.
Design: Retrospective matched-cohort study (2005-2020).
Article Synopsis
- People with HIV (PWH) are more vulnerable to severe outcomes from COVID-19, but there’s limited knowledge on their vaccination rates and factors influencing their vaccine completion.
- A study was conducted to assess COVID-19 vaccination coverage among PWH and analyze the demographics, clinical aspects, and community influences affecting their vaccination completion.
- Results showed that 90.5% of PWH completed the primary vaccine series by the end of 2021, with prior influenza vaccination being a significant factor for both the initial series and additional doses, while uncontrolled HIV viremia negatively impacted vaccination rates.
Article Synopsis
- COVID-19 vaccinations are effective in preventing severe illness and death but their impact on post-COVID conditions (PCC) is less understood, prompting a study to evaluate this association.
- The study analyzed electronic health records from over 161,000 vaccinated and unvaccinated COVID-19 patients from multiple healthcare systems, focusing on new diagnoses of PCC within six months after infection.
- Results showed that vaccinated individuals had a lower risk of several PCC categories, especially sensory and circulatory issues, while mental health disorders had a slightly higher risk in vaccinated individuals, indicating that vaccination may help reduce long-term COVID-19 consequences.
Article Synopsis
- A study re-evaluated mortality risks associated with COVID-19 vaccinations using a modified self-controlled case series design to minimize confounding biases.
- Researchers analyzed death data from vaccinated and unvaccinated individuals, focusing on non-COVID-19 mortality and specific cardiac-related deaths within set observation periods.
- Results for Pfizer-BioNTech showed reduced mortality risks for all outcomes, while Moderna and Janssen also indicated low risks, although some results for Moderna had confidence intervals that included 1, suggesting uncertainty in the estimates.
Impact of the COVID-19 Pandemic on Health Care Utilization in the Vaccine Safety Datalink: Retrospective Cohort Study.
JMIR Public Health Surveill
January 2024
Background: Understanding the long-term impact of the COVID-19 pandemic on health care utilization is important to health care organizations and policy makers for strategic planning, as well as to researchers when designing studies that use observational electronic health record data during the pandemic period.
Objective: This study aimed to evaluate the changes in health care utilization across all care settings among a large, diverse, and insured population in the United States during the COVID-19 pandemic.
Methods: We conducted a retrospective cohort study within 8 health care organizations participating in the Vaccine Safety Datalink Project using electronic health record data from members of all ages from January 1, 2017, to December 31, 2021.
Article Synopsis
- A large cohort study was conducted to assess the risk of non-COVID-19 mortality after vaccination, which is crucial to combat vaccine hesitancy, taking into account various demographic, clinical, and socioeconomic factors.
- The study analyzed data from seven Vaccine Safety Datalink sites, comparing non-COVID-19 mortality rates among vaccinated individuals with those who were not, across different age, sex, and racial/ethnic groups.
- The findings revealed lower non-COVID-19 mortality rates for vaccinated individuals, with adjusted hazard ratios indicating a significantly reduced risk after receiving COVID-19 vaccines, despite some remaining confounding bias.
Background: Shoulder injury related to vaccine administration (SIRVA) accounts for more than half of all claims received by the National Vaccine Injury Compensation Program. However, due to the difficulty of finding SIRVA cases in large health care databases, population-based studies are scarce.
Objective: The goal of the research was to develop a natural language processing (NLP) method to identify SIRVA cases from clinical notes.
Article Synopsis
- * Researchers analyzed data from over 10 million members across eight Vaccine Safety Datalink sites from 2017 to 2020, focusing on changes in incidence rates of specific health outcomes during different phases of the pandemic.
- * Results indicated that most outcomes, including serious conditions like encephalitis and acute disseminated encephalomyelitis, remained stable, while there was a notable decrease in incidence rates for several conditions during the early pandemic period.
Article Synopsis
- - The study explores the risk of shoulder conditions following intramuscular vaccinations, particularly in the deltoid muscle, using data from Kaiser Permanente Southern California between April 2016 and December 2017.
- - Out of over 3.7 million vaccinations, only 371 cases of shoulder conditions were identified, leading to an estimated incidence rate of 0.99 per 10,000 vaccinations, with higher risks noted in adults, especially women and older individuals.
- - Factors associated with increased risk included advanced age, female sex, specific vaccines, and simultaneous administration of vaccines among the elderly, indicating that certain populations may be more vulnerable to these shoulder issues post-vaccination.
By September 21, 2021, an estimated 182 million persons in the United States were fully vaccinated against COVID-19.* Clinical trials indicate that Pfizer-BioNTech (BNT162b2), Moderna (mRNA-1273), and Janssen (Johnson & Johnson; Ad.26.
View Article and Find Full Text PDFUnlabelled: This study highlights an unmet need in osteoporosis management, suggesting that beyond bone mineral density and fracture history, gender, fracture type, and age should be considered for fracture risk assessment. Following fragility fracture, men, patients with a spine or hip fracture, and those aged ≥ 65 have a higher disease burden.
Introduction: The objective of this study was to characterize osteoporosis-related fracture incidence and identify predictors of subsequent fractures and mortality.
Background: Dramatic decreases in outpatient visits and sudden increases in telehealth visits were observed during the COVID-19 pandemic, but it was unclear whether these changes differed by patient demographics and socioeconomic status.
Objective: This study aimed to assess the impact of the pandemic on in-person outpatient and telehealth visits (telephone and video) by demographic characteristics and household income in a diverse population.
Methods: We calculated weekly rates of outpatient and telehealth visits by age, sex, race/ethnicity, and neighborhood-level median household income among members of Kaiser Permanente Southern California (KPSC) from January 5, 2020, to October 31, 2020, and the corresponding period in 2019.
Background: The COVID-19 pandemic has caused an abrupt reduction in the use of in-person health care, accompanied by a corresponding surge in the use of telehealth services. However, the extent and nature of changes in health care utilization during the pandemic may differ by care setting. Knowledge of the impact of the pandemic on health care utilization is important to health care organizations and policy makers.
View Article and Find Full Text PDFSARS-CoV-2 Infection Among Hospitalized Pregnant Women: Reasons for Admission and Pregnancy Characteristics - Eight U.S. Health Care Centers, March 1-May 30, 2020.
MMWR Morb Mortal Wkly Rep
September 2020
Pregnant women might be at increased risk for severe coronavirus disease 2019 (COVID-19), possibly related to changes in their immune system and respiratory physiology* (1). Further, adverse birth outcomes, such as preterm delivery and stillbirth, might be more common among pregnant women infected with SARS-CoV-2, the virus that causes COVID-19 (2,3). Information about SARS-CoV-2 infection during pregnancy is rapidly growing; however, data on reasons for hospital admission, pregnancy-specific characteristics, and birth outcomes among pregnant women hospitalized with SARS-CoV-2 infections are limited.
View Article and Find Full Text PDFBackground: Bisphosphonates are effective in reducing hip and osteoporotic fractures. However, concerns about atypical femur fractures have contributed to substantially decreased bisphosphonate use, and the incidence of hip fractures may be increasing. Important uncertainties remain regarding the association between atypical femur fractures and bisphosphonates and other risk factors.
View Article and Find Full Text PDFObjective: To explore potential weight-related disparities in the quality of care for adults with diabetes in a large managed care health plan according to recommended quality indicators.
Design: Cross-sectional analysis.
Methods: A total of 164,721 Kaiser Permanente Southern California members aged 18 to 75 years with diabetes who had 1 or more health encounters with a weight and height measurement between July 1, 2007, and June 30, 2008, were identified.