FAIR, ethical, and coordinated data sharing for COVID-19 response: a scoping review and cross-sectional survey of COVID-19 data sharing platforms and registries.

Data sharing is central to the rapid translation of research into advances in clinical medicine and public health practice. In the context of COVID-19, there has been a rush to share data marked by an explosion of population-specific and discipline-specific resources for collecting, curating, and disseminating participant-level data. We conducted a scoping review and cross-sectional survey to identify and describe COVID-19-related platforms and registries that harmonise and share participant-level clinical, omics (eg, genomic and metabolomic data), imaging data, and metadata.

Heterogeneous Electrochemical Ammonia Oxidation with a Ru-bda Oligomer Anchored on Graphitic Electrodes via CH-π Interactions.

Molecular catalysts can promote ammonia oxidation, providing mechanistic insights into the electrochemical N cycle for a carbon-free fuel economy. We report the ammonia oxidation activity of carbon anodes functionalized with the oligomer {[Ru(bda-κ- )(4,4'-bpy)](4,4'-bpy)}, , where bda is [2,2'-bipyridine]-6,6'-dicarboxylate and 4,4'-bpy is 4,4'-bipyridine. Electrocatalytic studies in propylene carbonate demonstrate that the Ru-based hybrid anode used in a 3-electrode configuration transforms NH to N and H in a 1:3 ratio with near-unity faradaic efficiency at an applied potential of 0.

The Impact of a Proton Relay in Binuclear α-Diimine-Mn(CO) Complexes on the CO Reduction Catalysis.

Herein, we describe the redox chemistry of bi- and mononuclear α-diimine-Mn(CO) complexes with an internal proton source in close proximity to the metal centers and their catalytic activity in the electrochemically driven CO reduction reactions. In order to address the impact of the two metal sites and of the proton source, we investigate a binuclear complex with phenol moiety, , a binuclear Mn complex with methoxyphenol unit instead, , and the mononuclear analogue with a phenol unit, . Spectroelectrochemical investigation of the complexes in dmf under a nitrogen atmosphere indicates that and undergo a reductive H formation forming [Mn(HL)(CO)Br] and [Mn(HL)(CO)], respectively, which is redox neutral for the complex and equivalent to a deprotonation of the phenol unit.

Site-directed and global incorporation of orthogonal and isostructural noncanonical amino acids into the ribosomal lasso peptide capistruin.

Expansion of the structural diversity of peptide antibiotics was performed through two different methods. Supplementation-based incorporation (SPI) and stop-codon suppression (SCS) approaches were used for co-translational incorporation of isostructural and orthogonal noncanonical amino acids (ncAAs) into the lasso peptide capistruin. Two ncAAs were employed for the SPI method and five for the SCS method; each of them probing the incorporation of ncAAs in strategic positions of the molecule.

Conformational investigation of antibiotic proximicin by X-ray structure analysis and quantum studies suggest a stretched conformation of this type of γ-peptide.

The proximicins A-C are naturally occurring cytotoxic γ-peptides that contain the unique 4-amino-furan-carboxylic acid. In contrast to the structurally related cytotoxic natural DNA binder netropsin and distamycin, both exhibiting as core building block N-methyl-4-amino-pyrrol-carboxylic acid, no DNA binding was observed for the procimicins. X-ray analysis of crystals of a protected 4-amino-furan-2-carboxylic acid dipeptide revealed a stretched conformation.

In vitro chemoenzymatic and in vivo biocatalytic syntheses of new beauvericin analogues.

New beauvericins have been synthesized using the nonribosomal peptide synthetase BbBEAS from the entomopathogenic fungus Beauveria bassiana. Chemical diversity was generated by in vitro chemoenzymatic and in vivo whole cell biocatalytic syntheses using either a B. bassiana mutant or an E.

[A combined lesion of the digestive organs and chronic inflammatory diseases of the large intestine].

An analysis was carried out of 222 medical records and autopsies from patients with inflammatory diseases of the large intestine, the immediate causes of death of whom were different disorders. The incidence of hepatitis running an active course correlated with age of patients and came up to 58.8% in the group of subjects 20 to 40 years old.

[Microcirculatory changes in patients with chronic diseases of the biliary tract].

Condition was studied of the microcirculatory bed in 80 patients with chronic noncalculous cholecystitis and 38 patients with calculous cholecystitis with the aid of biomicroscopy of bulbar conjunctiva and histological examination of removed gallbladders. Changes in microcirculation were characterized by enhancement of arteriole-venous shunting, diminution of the number of the functioning capillaries, appearance of signs of venous congestion, lowering of microvessel reactivity in an acute nitroglycerin test, which fact may suggest their systemic character.

[Manifestations of domain organization of the Staphylococcus aureus protein A during heat denaturation of its structure].

Melting of protein A from Staphylococcus aureus has been studied in neutral medium by the methods of microcalorimetry and circular dichroism. The melting process of protein A is shown to consist of, at least, 5 independent transitions. The transition with the heat absorption maximum at 38 degrees is ascribed to the melting of the C-terminal domain of protein A.