[The limitation of glucose catabolism as a factor in protection during hypoxia].

Violuric acid was first shown to have antihypoxic and antioxidative properties, to exert protective action in sodium nitrite-induced hemic hypoxia. Hepatic glucose and glucogen levels increased, the activity of glucose-6- phosphodihydrogenase enhanced, while that of lactate dehydrogenase and alkaline phosphatase decreased, the content of cAMP restored, whereas cGMP and 2,3-diphosphoglycerate levels decreased to a greater extent. The action of violuric acid was especially evident at the ultrastructural level-the ultrastructure of brush receptor elements in anoxia in the presence of violuric acid's action retained all the features characteristic for intact animals, which was accompanied by a significant accumulation of glycogen in the neuroplasm.

[The mechanism of action of the bioflavonoid lespeflan and the antihypoxant TB-4 on nitrogen metabolism in animals with acute kidney failure].

The changes in the levels of urea and creatinine caused by the new native preparation lespeflanum and the antihypoxant TB-4 were studied in animal experiments. The agents tested produced a significant hypoazotemic effect in acute renal failure. Lespeflanum showed diuretic and natriuretic effects in healthy animals, elevated plasma aldosterone levels and decreased hepatic arginase activity.

[Brevikarin dihydrochloride--a new original anti-arrhythmia agent].

On six models of arrhythmias of atrial and ventricular types (induced by administration of aconitine, chlorcalcium, chlorbarium, strophanthin, chloroform-adrenaline and by coronary occlusion) it was shown that in rats, cats and rabbits the antiarrhythmic, preventive and relieving activity of brevicarine dichlorhydrate exceeded that of quinidine, novocainamide and lidocaine in power by 3-5 times and in duration by 3-18 times.

[Effect of antihypoxic agents on the cyclic nucleotide content in different brain structures in normo-oxia and hypoxia].

A study was made of the effects of isothiobarbamine and guthimine (10 and 50 mg/kg, respectively) on the content of cAMP and cGMP in the brain cortex (BC) and hippocamp under normal conditions and hypoxia. Isothiobarbamine did not change the content of both cyclic nucleotides under normoxia, whereas under hypoxia it reduced the level of the cyclic nucleotides in the BC and raised it in the hippocamp. Guthimine increased their content in the BC and did not change it in the hippocamp under normoxia, whereas under hypoxia it increased the cAMP content in the hippocamp and did not change it in the BC.

[Method of assessing the effect of preparations on the ulcerogenic action of reserpine in mice].

A method for intraperitoneal (2.5 mg/kg) or enteral (10 mg/kg) administration of reserpine to mice with subsequent keeping for 2 hours at a temperature of 7 degrees C and for 16 hours at a temperature maintained at the animal house has been suggested to induce lesions of the glandular part of the stomach. The lesions have been subjected to histological study.

[Anti-ulcer action of a decoction of the flowers of the dropwort, Filipendula ulmaria (L.) Maxim].

The decoction (1 : 10, 1 : 20) from flowers of Filipendula ulmaria (L.) Maxim. reduces the ulcerogenic action of such procedures as ligation of the pylorus, immobilization or fixation of rats.

[Effects of acute and chronic alcohol poisoning on the noradrenaline content in the rat hypothalamus].

The content and distribution of norepinephrine in the hypothalamus following acute and chronic alcohol opisoning of animals (by introducing of a 20 degrees alcohol by mouth) was studied by applying biochemical and flurorscence histochemical methods. After poisoiing the content of neorpinephrine in the hypothalamus increased twice as compared with controls and continued to be high for 3 months. This was attended by a greater fluorescence intensity in the noradrenergic fibres, in the areas of the hypothalamic supra-optic nuclei and an inhibition of the transport and release of the neurosecretory material in the supra-optic neurohypophysial system was observed.

[Mechanism of the action of apressin under conditions of high temperature and physical exertion].

In experiments on rats subject to study were regularities governing the metabolism of glycogen, milk, pyruvic acid, phosphocreatine in the liver tissues, cortex, musculus gastrocnemius and in the myocardium, as well as of acids in the peripheral blood at 40 degrees C of outside temperature, 95 per cent humidity and during swimming. Investigations also covered preventive application of apressin in rats. The influence of stress was found to produce metabolic changes in the organism of rats.

[Electrical activity of the vagus nerve with high external temperatures].

In dogs with electrodes implanted in fundal gastric branch and with the stomach fistula, the spontaneous bioelectric activity in the n. vagus increased when the periodical motoric action of the stomach occurred. The injection of morphin (0.