Publications by authors named "Denise de Castro Fernandes"
Article Synopsis
- * Dysfunction in the endothelial nitric oxide synthase (eNOS) leads to the production of harmful superoxide anion, contributing to a pro-oxidant environment that facilitates melanoma growth and resistance to treatment.
- * Research indicates that restoring eNOS activity can reduce tumor growth and enhance the effectiveness of chemotherapy, suggesting that targeting eNOS dysfunction could be a promising strategy for melanoma therapy.
Background: Nitroarachidonic acid (NOAA) exhibits pleiotropic anti-inflammatory actions in a variety of cell types. We have recently shown that NOAA inhibits phagocytic NADPH oxidase 2 (NOX2) by preventing the formation of the active complex. Recent work indicates the participation of protein disulfide isomerase (PDI) activity in NOX2 activation.
View Article and Find Full Text PDFThiol proteins may potentially act as redox signaling adaptor proteins, adjusting reactive oxygen species intermediates to specific signals and redox signals to cell homeostasis. In this review, we discuss redox effects of protein disulfide isomerase (PDI), a thioredoxin superfamily oxidoreductase from the endoplasmic reticulum (ER). Abundantly expressed PDI displays ubiquity, interactions with redox and nonredox proteins, versatile effects, and several posttranslational modifications.
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