Publications by authors named "Denise Vecchie"
Evidence suggests that angiotensin-converting enzyme inhibitors (ACEIs) may increase metabolic rate by promoting thermogenesis, potentially through enhanced fat oxidation and improved insulin. More research is, however, needed to understand this intricate process. In this study, we used 22 lines from the Genetic Reference Panel to assess the metabolic rate of virgin female and male flies that were either fed a standard medium or received lisinopril for one week or five weeks.
View Article and Find Full Text PDFBackground: Syndecan-4 (SDC4) is a member of the heparan sulfate proteoglycan family of cell-surface receptors. We and others previously reported that variation in the SDC4 gene was associated with several components of the metabolic syndrome, including intra-abdominal fat, fasting glucose and triglyceride levels, and hypertension, in human cohorts. Additionally, we demonstrated that high fat diet (HFD)-induced obese female mice with a Sdc4 genetic deletion had higher visceral adiposity and a worse metabolic profile than control mice.
View Article and Find Full Text PDFArticle Synopsis
- - Syndecans are proteins that connect to the extracellular matrix and may have important roles in metabolic health, especially linked to various fat and glucose levels in different populations.
- - A study was conducted on mice to examine the effects of deleting the syndecan gene while feeding them a high-fat diet; both sexes initially gained weight similarly, but the female mice showed significant metabolic issues compared to the controls.
- - Female syndecan-deficient mice experienced increased body fat, higher cholesterol and triglyceride levels, and lower insulin sensitivity, along with changes in fat tissue and liver function, highlighting the gene's potential role in obesity and related health issues.