Publications by authors named "Denise So"
Article Synopsis
- DrugBank, launched in 2006, is a leading resource for drug and pharmaceutical information, receiving over 30 million views annually.
- The recent update, DrugBank 6.0, has significantly expanded its database, increasing the number of FDA approved drugs by 72% and investigational drugs by 38%.
- Enhancements include thousands of new pathways for drug mechanisms, improved datasets for 11,891 drugs, and added experimental data like MS/MS spectra for nearly 9,500 small molecule drugs, making it more valuable for researchers across multiple fields.
Systemic infection modifies the neuroinflammatory response in late stage Alzheimer's disease.
Acta Neuropathol Commun
September 2018
Clinical studies indicate that systemic infections accelerate cognitive decline in Alzheimer's disease. Animal models suggest that this may be due to enhanced pro-inflammatory changes in the brain. We have performed a post-mortem human study to determine whether systemic infection modifies the neuropathology and in particular, neuroinflammation, in the late-stage of the disease.
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