Publications by authors named "Denise S Matias"

Purpose: To test the predictive value of ophthalmic artery (OA) Doppler velocimetry in relation to the occurrence of hypertensive disorders of pregnancy (HDP).

Methods: We compared, by analysis of variance, the values of seven OA Doppler variables (peak systolic velocity, second systolic peak velocity [P2], mean velocity, end diastolic velocity, resistance index [RI], pulsatility index [PI], and peak ratio) of 31 women with preeclampsia and 33 women with gestational hypertension vs those of 227 women without HDP. The prognostic value of these variables in relation to the occurrence of HDP was evaluated by the area under the curve (AUC) receiver operating characteristic curve.

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Objectives: The purposes of this study were to describe ophthalmic artery Doppler parameters in pregnant women at risk for preeclampsia in the second trimester, compare them with reference values described in women with healthy pregnancies, and evaluate the association between gestational age and Doppler parameters.

Methods: We conducted an observational study with prospective data collection in which measurements of 7 ophthalmic artery Doppler parameters were obtained in 274 women at 20 to 28 weeks' gestation with clinical risk factors for preeclampsia. The following measurements were obtained: peak systolic velocity, mesodiastolic velocity, mean velocity, end-diastolic velocity, resistive index, pulsatility index, and peak ratio.

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Hypertension is one of the most common clinical complications during pregnancy. Preeclampsia, in particular, still accounts for high maternal and fetal morbidity and mortality. Hemodynamic studies have shown that general arteriolar vasoconstriction, which leads to hypoperfusion of target organs, including the eye area, remains the most significant pathological change in preeclampsia.

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