Publications by authors named "Denise S M Boulanger"
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Synopsis of recent research by authors named "Denise S M Boulanger"
- Denise S M Boulanger's research focuses on the mechanisms by which tumor-specific CD8 T cells and MHC I molecules interact to influence immunotherapy outcomes and T cell responses to tumors and infections, particularly the role of tapasin in editing peptide presentation.
- Recent findings highlight that reactivation of low avidity tumor-specific CD8 T cells can enhance the efficacy of anti-PD-1 treatment, indicating that the diversity of T cell responses is critical in overcoming T cell exhaustion and resistance.
- Boulanger's work also emphasizes the importance of peptide kinetics and abundance in MHC I peptide editing, which provides insights into how T cell immunodominance is shaped by the expression of tapasin in the immune response to viruses and cancers.
