Tissue ingrowth into perforated polymethylmethacrylate orbital implants: an experimental study.

Purpose: To evaluate the clinical response and fibrovascular ingrowth into perforated acrylic orbital implants in a rabbit model.

Methods: Perforated implants were manufactured by drilling channels interconnected at the center in conventional 12- to 13-mm acrylic spheres. The implants were placed in 16 eviscerated eyes with posterior sclerotomy of 16 New Zealand white rabbits.

[Biodegradable systems containing prednisolone acetate for orbital administration].

Purpose: The present study aimed to evaluate an injectable extended-release formulation of prednisolone acetate (PA) for orbital administration.

Methods: Microspheres (MEs) of poly-e-caprolactone (PCL) containing PA were developed by the method of solvent evaporation. The MEs obtained were characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), encapsulation efficiency and in vitro release profile.

Activated satellite cells in medial rectus muscles of patients with strabismus.

Purpose: The goal of this study was to determine whether the medial rectus muscles of patients with a history of medial rectus underaction or overaction show alterations in the process of satellite cell activation when compared with normal age-matched control muscles.

Methods: Medial rectus muscles were obtained with consent from adult patients undergoing surgical resection due to medial rectus underaction or overaction and were prepared for histologic examination by fixation and paraffin embedding. Control muscles were obtained from cornea donor eyes of adults who had no history of strabismus or neuromuscular disease.