Publications by authors named "Denise Mennerich"
Article Synopsis
- The study investigates the natural compound diphyllin's effectiveness against SARS-CoV-2, the virus responsible for COVID-19, particularly against various variants like Alpha, Beta, Delta, and Omicron.
- Results show that diphyllin inhibits the virus's entry into cells in a dose-dependent manner by disrupting critical processes required for viral entry.
- The research highlights diphyllin's potential as a dual-action antiviral agent by targeting both endosomal and cell surface pathways involved in SARS-CoV-2 entry.
Article Synopsis
- The COVID-19 pandemic has created a significant need for affordable and effective treatments, especially as the search for alternative therapies continues even with vaccine availability.
- Research tested herbal teas, specifically those made from perilla and sage, and found that they have strong antiviral effects against SARS-CoV-2, performing comparably to some existing treatments.
- Key compounds like caffeic acid and perilla aldehyde were identified in these teas, and the study suggests they work by activating certain protective mechanisms in the body, indicating potential for herbal remedies in managing COVID-19.
(COVID-19) caused by the emerging (SARS-CoV-2) has set off a global pandemic. There is an urgent unmet need for safe, affordable, and effective therapeutics against COVID-19. In this regard, drug repurposing is considered as a promising approach.
View Article and Find Full Text PDFThe coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently the most pressing medical and socioeconomic challenge. Constituting important correlates of protection, the determination of virus-neutralizing antibodies (NAbs) is indispensable for convalescent plasma selection, vaccine candidate evaluation, and immunity certificates. In contrast to standard serological ELISAs, plaque reduction neutralization tests (PRNTs) are laborious, time-consuming, expensive, and restricted to specialized laboratories.
View Article and Find Full Text PDFBackground: The bioconversion of lignocellulosic biomass in various industrial processes, such as the production of biofuels, requires the degradation of hemicellulose. is a thermophilic bacterium, well known for its outstanding hemicellulose-degrading capability. Its genome comprises about 50 genes for partially still uncharacterised thermostable hemicellulolytic enzymes.
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