Public Health.

Background: Due to multiple benefits of sustained exercise and physical activity, it is important to understand factors that can facilitate regular engagement in physical activity in later adulthood. Prior work found that a more positive affective response to acute exercise was associated with greater physical activity levels in younger adults. However, this determinant has been understudied in older adults and individuals at risk of Alzheimer disease (AD).

Driving cessation over a 24-year period: Dementia severity and cerebrospinal fluid biomarkers.

Introduction: With 36 million older adult U.S. drivers, safety is a critical concern, particularly among those with dementia.

Preclinical Alzheimer's disease and longitudinal driving decline.

Introduction: Links between preclinical AD and driving difficulty onset would support the use of driving performance as an outcome in primary and secondary prevention trials among older adults (OAs). We examined whether AD biomarkers predicted the onset of driving difficulties among OAs.

Methods: 104 OAs (65+ years) with normal cognition took part in biomarker measurements, a road test, clinical and psychometric batteries and self-reported their driving habits.

Amyloid Imaging, Cerebrospinal Fluid Biomarkers Predict Driving Performance Among Cognitively Normal Individuals.

Postmortem brain studies of older drivers killed in car accidents indicate that many had Alzheimer disease (AD) neuropathologic changes. We examined whether AD biomarkers are related to driving performance among cognitively normal older adults. Individuals with normal cognition, aged 65+ years, and driving at least once per week, were recruited.