Low-dose growth hormone administration mobilizes endothelial progenitor cells in healthy adults.

Objective: Endothelial progenitor cells (EPCs) mobilize from the bone marrow secondary to a stimulus and home to sites of injury, where they differentiate into endothelial cells and contribute to the repair of damaged vasculature. We hypothesized that growth hormone (GH) administration would increase the number of circulating EPCs in adults and thereby represent a mechanism to enhance vascular health.

Design: A prospective trial of low-dose GH (0.

Markedly impaired fibrinolytic balance contributes to cardiovascular risk in adults with growth hormone deficiency.

Context: Adults with GH deficiency (GHD) have multiple cardiovascular risk factors, including an unfavorable lipid profile and body composition as well as impairments in endothelial function and cardiac performance. We hypothesized that GHD is associated with elevated levels of plasminogen activator inhibitor-1 (PAI-1), the major inhibitor of plasminogen activation in the circulation.

Objective: The objective of the study was to determine the fibrinolytic profile of adults with GHD in comparison with controls.

Disorders of water metabolism following transsphenoidal pituitary surgery: a single institution's experience.

Disorders of water metabolism are a common complication of pituitary surgery. The primary purpose of this study was to determine the incidence and duration of post-surgical diabetes insipidus (DI) at our institution. Secondary objectives included characterizing the incidence of post-operative hyponatremia as well as delineating factors associated with the onset of these complications.