Publications by authors named "Denise Josephina Johanna Hermans"

Background: Infantile hemangiomas (IHs) are common and mostly emerge in the head-neck area. Recently, propranolol has been replacing oral corticosteroids (OCS) as the main treatment modality.

Objectives: The aim of this study was to explore the impact of treatment, contentment with treatment outcome and quality of life for families and patients with cervicofacial IHs, treated with propranolol versus OCS.

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Objectives: Infantile hemangiomas (IHs) in the airway may be potentially life-threatening during the proliferative phase. Available treatments like oral corticosteroids (OCS) and chemotherapeutic agents usually showed variable responses and serious side effects. Propranolol is a new and promising treatment option.

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Kaposiform hemangioendothelioma is a rare vascular tumor in children. Especially, in association with the Kasabach-Merritt Phenomenon it can be life threatening. The management of these patients is very difficult and an aggressive treatment regime is required.

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Background: Ulceration is a common but poorly understood complication of infantile hemangiomas (IH) that is difficult to control.

Objective: To investigate the possible role of monotherapy with propranolol for ulcerating IH.

Methods: Propranolol was given to 20 patients with IH, who suffered from ulceration at the start of treatment (mean age at onset of treatment, 3.

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Article Synopsis
  • The study analyzed records of 465 patients with infantile hemangiomas to compare characteristics between ulcerated and non-ulcerated cases, finding that 23% exhibited ulceration.
  • Ulcerated hemangiomas were significantly larger, often located in the head-neck and anogenital regions, and more likely to have a superficial component, with ulceration occurring mostly during the hemangioma's proliferation phase.
  • The research suggests that larger, superficial hemangiomas in trauma-prone areas are more prone to ulceration, helping in assessing individual patient risk.
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