Publications by authors named "Denise Iliff"
Article Synopsis
- Chronic intervertebral disc degeneration causes significant disability and requires better understanding of tissue interactions for effective treatments.
- A rat model of discogenic pain was used to observe changes in disc degeneration and inflammation in both the disc and spinal regions following an annulus fibrosus injury.
- The study found that the injury triggers a cascade of inflammation and cellular changes in the spinal cord and dorsal root ganglia, leading to chronic pain mechanisms and indicating the need for targeted therapies at different stages of inflammation.
Intervertebral disc (IVD) degeneration with Modic-like changes is strongly associated with pain. Lack of effective disease-modifying treatments for IVDs with endplate (EP) defects means there is a need for an animal model to improve understanding of how EP-driven IVD degeneration can lead to spinal cord sensitization. This rat in vivo study determined whether EP injury results in spinal dorsal horn sensitization (substance P, SubP), microglia (Iba1) and astrocytes (GFAP), and evaluated their relationship with pain-related behaviors, IVD degeneration, and spinal macrophages (CD68).
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