Publications by authors named "Denise Gilgen"
Background & Aims: Interobserver differences in endoscopic assessments contribute to variations in rates of response to placebo in ulcerative colitis (UC) trials. We investigated whether centralized review of images could reduce these variations.
Methods: We performed a 10-week, randomized, double-blind, placebo-controlled study of 281 patients with mildly to moderately active UC, defined by an Ulcerative Colitis Disease Activity Index (UCDAI) sigmoidoscopy score ≥2, that evaluated the efficacy of delayed-release mesalamine (Asacol 800-mg tablet) 4.
Context: Maintenance therapy for Crohn disease features the use of immunosuppressive drugs, which are associated with an increased risk of infection. Identification of safe and effective maintenance strategies is a priority.
Objective: To determine whether the oral administration of omega-3 free fatty acids is more effective than placebo for prevention of relapse of Crohn disease.
Background: Migration, particularly when associated with exposure to organized violence, can seriously affect mental and physical health in ways that are not obvious. This study considers the clinical impact of organized violence on emotional and somatic problems encountered in the course of primary health care.
Methods: Migrant patients from Bosnia (n=36) and Turkey (n=62) in primary care were recruited into the study and divided into two groups: male and female migrants of both countries who reported experience of organized violence and those who did not.