Publications by authors named "Denise Feick"
Article Synopsis
- Quinidine is an antiarrhythmic drug that inhibits CYP2D6 and P-glycoprotein, making it important for studying drug-drug interactions (DDIs), but it's also affected by interactions with CYP3A4 and P-gp since it's a substrate of these proteins.
- A physiologically-based pharmacokinetic (PBPK) model of quinidine was developed to analyze how it absorbs, distributes, metabolizes, and is excreted in the body, also involving its metabolite, 3-hydroxyquinidine.
- The model demonstrated high accuracy, successfully simulating complex DDI scenarios with over 90% of predicted outcomes aligning closely with actual clinical data, and it will be made
Article Synopsis
- Tacrolimus, an immunosuppressant drug, is primarily metabolized by the enzymes CYP3A4 and CYP3A5, resulting in significant variability in how different individuals process the drug due to factors like food intake and genetic differences.
- The development of a whole-body pharmacokinetic model for tacrolimus using PK-Sim® allows researchers to predict how food-drug interactions and drug-drug interactions affect its pharmacokinetics.
- The model showed strong predictive capabilities, accurately aligning with observed data for both food and drug interactions, and has potential applications in improving drug discovery and personalized dosing strategies.