Publications by authors named "Denise Dias de Oliveira"
Article Synopsis
- Research shows that vitexin, a glycosylated flavonoid, can reduce seizures in rats induced by pentylenetetrazole (PTZ).
- The study aimed to explore the long-term effects of vitexin on PTZ-induced epilepsy in rats through repeated doses.
- Results indicated that chronic treatment with vitexin lowered seizure severity without negatively impacting kidney or liver function, similar to diazepam.
Different types of epilepsy and forms of pathological anxiety have been described as significant neurological disorders that may exist as comorbidities. Some of those disorders share the association of affected limbic areas/neuropathological triggers as well as the use of drugs for their clinical management. The aim of this work was to investigate the anticonvulsant and anxiolytic properties of the vitexin (apigenin-8-C-glucoside), since this compound is a flavonoid usually found as one of the major constituents in several medicinal plants claimed as anxiolytics and/or anticonvulsants.
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