Publications by authors named "Denise Defayay"
Article Synopsis
- Guanine quadruplexes are interesting tetra-stranded nucleic acid structures that could lead to new anticancer treatments due to their unique properties.
- The complex nature of guanine quadruplexes makes it hard to specifically target certain sequences, which is a challenge for therapeutic development.
- Researchers are creating luminescent platinum(II) complexes with extra nucleobases attached to improve targeting capabilities and have begun to evaluate how different nucleobase attachments affect the metal complex's affinity for various DNA sequences.
The use of imidazole-4-carboxylate (X) as an artificial nucleobase in metal-mediated base pairing is reported. Towards this end, the corresponding deoxyribonucleoside was synthesized and structurally characterized as its sodium salt (sodium 1,2-dideoxy-1-(4-carboxyimidazol-1-yl)-d-ribofuranose). The deoxyribonucleoside was incorporated into different DNA duplexes (parallel-stranded and antiparallel-stranded), and their Cu(II)- and Ag(I)-binding behavior was investigated.
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