Publications by authors named "Denise D Young"
Objectives: Oral viscous budesonide (OVB) is a common medication used to treat eosinophilic esophagitis (EoE). It is typically mixed with Splenda to produce a slurry, but other delivery vehicles have been used in clinical practice. We aimed to evaluate outcomes of pediatric EoE patients treated with OVB using different drug delivery vehicles.
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- Systemic steroids are effective for treating inflammatory bowel disease (IBD) but are not suitable for long-term use, prompting the need for a structured weaning process.
- A quality improvement initiative was implemented to enhance the steroid weaning protocol for new IBD patients, focusing on communication, symptom evaluation, and a structured tapering schedule.
- Results showed significant improvements, including an 80% increase in patient follow-ups, a reduction in steroid use by about 17 days, and 61.1% of patients successfully weaned off steroids within 8 weeks, all without increased hospital admissions.
Background: 5-aminosalicylates (5-ASA) are used to treat mild to moderate ulcerative colitis. Despite their lack of efficacy in Crohn disease (CD), they are still used in real-world practice. Additionally, when patients have progressive disease, they may escalate to biologic therapy, at which time 5-ASA may or may not be discontinued.
View Article and Find Full Text PDFAminoacyl-tRNA synthetases (ARSs) are crucial enzymes for protein translation. Mutations in genes encoding ARSs are associated with human disease. Tyrosyl-tRNA synthetase is encoded by which is ubiquitously expressed and implicated in an autosomal dominant form of Charcot-Marie-Tooth and autosomal recessive related multisystem disease.
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