Publications by authors named "Denis V Petrovsky"
Article Synopsis
- * Alpha-synuclein, which can aggregate and harm cells, interacts with cyclophilin A to prevent these destructive aggregations, highlighting the importance of chaperone proteins.
- * Using advanced molecular docking techniques, we identified how alpha-synuclein, cyclophilin A, and Anle138b can form a stable complex, primarily through hydrophobic and hydrogen bonding interactions.
A super-secondary structure (SSS) is a spatially unique ensemble of secondary structural elements that determine the three-dimensional shape of a protein and its function, rendering SSSs attractive as folding cores. Understanding known types of SSSs is important for developing a deeper understanding of the mechanisms of protein folding. Here, we propose a universal PSSNet machine-learning method for SSS recognition and segmentation.
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- * A study of 3,661 healthy athletes used various medical examinations and machine learning to analyze health indicators related to recovery post-competition.
- * Key findings indicated that muscle metabolism parameters (like aspartate aminotransferase and creatine kinase) and ornithine cycle parameters (like creatinine and urea) were crucial for distinguishing between catabolic and anabolic metabolism in athletes.
Article Synopsis
- - This study examined how 3β-corner super-secondary structures maintain their stability in water, independent of protein globules, using molecular dynamics (MD) simulations.
- - Researchers analyzed various geometric parameters, like gyration radius and hydrogen bonds, and characterized a set of 3β-corner structures to show they consistently retained their formation.
- - The findings suggest that 3β-corners are stable in aqueous environments and could serve as essential building blocks for protein folding and offer a standalone focus for structural biology research.
Article Synopsis
- * JAK and STAT proteins play key roles in signaling processes related to inflammation and are important in autoimmune diseases like rheumatoid arthritis.
- * The study explored how the drug ruxolitinib interacts with JAK1 and JAK2, showing it binds selectively to these proteins with strong binding affinities, mainly through hydrophobic interactions.
Mass spectrometric profiling provides information on the protein and metabolic composition of biological samples. However, the weak efficiency of computational algorithms in correlating tandem spectra to molecular components (proteins and metabolites) dramatically limits the use of "omics" profiling for the classification of nosologies. The development of machine learning methods for the intelligent analysis of raw mass spectrometric (HPLC-MS/MS) measurements without involving the stages of preprocessing and data identification seems promising.
View Article and Find Full Text PDFThe association between cancer risk and schizophrenia is widely debated. Despite many epidemiological studies, there is still no strong evidence regarding the molecular basis for the comorbidity between these two pathological conditions. The vast majority of assays have been performed using clinical records of schizophrenic patients or those undergoing cancer treatment and monitored for sufficient time to find shared features between the considered conditions.
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