Publications by authors named "Denis Urban"
Article Synopsis
- In acute promyelocytic leukemia (APL), combining all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) shows a unique effect on differentiation syndrome (DS), making it different from the previously recognized ATRA syndrome due to its specific symptoms and patterns.
- A study from 2013-2022 categorized APL patients into three treatment groups and analyzed the occurrence of leukocytosis and DS within the first 25 days, finding a 43.8% incidence of DS and elevated liver enzymes in the ATRA/ATO standard-risk group.
- The results suggest that liver changes may be linked to the treatment's effects on leukocyte differentiation and call for a reevaluation of the DS definition and
