Publications by authors named "Denis Meleard"

Objectives: To determine hemostasis perturbations, including von Willebrand factor (VWF) multimers, after implantation of a new bioprosthetic and pulsatile total artificial heart (TAH).

Design: Preclinical study SETTING: Single-center biosurgical research laboratory.

Participants: Female Charolais calves, 2-to-6 months old, weighing 102-to-122 kg.

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Article Synopsis
  • * Two patients, unable to receive heart transplants and in imminent risk of death, underwent successful C-TAH implantation, with both showing rapid recovery post-surgery.
  • * Despite initial success, one patient later died due to device failure, with autopsy findings showing no significant clot formation in the bioprosthesis.
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Objectives: The Carmat bioprosthetic total artificial heart (TAH) contains bioprosthetic blood-contacting surfaces, and is designed for orthotopic cardiac replacement. In preparation for clinical studies, we evaluated the TAH performance and its effects on end-organ function in an animal model.

Methods: Twelve female Charolais calves, 2-3 months of age and weighing 102-122 kg, were implanted with the TAH through a mid-sternotomy to ensure an adequate anatomic fit.

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