Psychogenic carcinogenesis: carcinogenesis is without exogenic carcinogens.

The history of researches of a problem of cancer has cleared a number of key cellular-molecular-genetic mechanisms of carcinogenesis, however process of carcinogenesis, is still out of control and a world forecast is unfavorable despite the advanced pathogenetically focused medication and excellent results of cancer treatment in vivo. Numerous researches have shown that chronic psycho-emotional stress by means of stressful hormones and endogenous mutagens (reactive oxygen and nitrogen species) are capable to damage cells DNA and to compromise immune system. Actually, chronic psycho-emotional stress is capable to activate the key mechanisms of carcinogenesis.

Xenovaccinotherapy for colorectal cancer.

The objectives of this phase I-II trial were to assess the toxicity, immunological and clinical responses induced in 37 patients with stage IV colorectal cancer by the subcutaneous administration of a xenogenic polyantigenic vaccine (XPV) prepared from disrupted murine melanoma (B16) and carcinoma (LLC) cells. An inducing course of vaccinotherapy consisted of 10 immunizations (5 at weekly and 5 at fortnight intervals). Twenty-four hours later each of first 5 vaccinations the patient was subcutaneously given a low dose of the recombinant interleukin-2 (IL-2).

Xenovaccinotherapy for melanoma.

The objectives of this phase I-II trial were to assess the toxicity, immunological and clinical responses induced in stage III/IV melanoma patients by the subcutaneous administration of xenogenic polyantigenic vaccine (XPV) prepared from disrupted murine melanoma (B16) and carcinoma (LLC) cells. An inducing course of vaccinotherapy consisted of ten immunizations (five at weekly and five at fortnight intervals). Twenty-four hours following each of the first five vaccinations, the patient was subcutaneously given a low dose of the recombinant interleukin-2 (IL-2).

Cell transplantation therapy in re-animating severely head-injured patients.

The results of controlled, retrospective clinical investigation of applying cell transplantation (CT) therapy in 38 severely head-injured patients are presented. The patients initially were in state of coma (Glasgow coma scale score 3--7), owing to their traumatic brain injuries. Cells prepared from fetal nervous and hematopoietic tissues were grafted subarachnoidally via lumbar puncture.

Erythroid cells in immunoregulation: characterization of a novel suppressor factor.

Nucleated erythroid cells (EC) have been previously reported to possess a potent natural suppressor (NS) activity for B-cell responses. In this study, we demonstrate that murine EC are able to reduce not only lipopolysaccharide (LPS)-driven B-cell proliferation, but also proliferative and cytotoxic T-cell responses generated in a primary allogeneic mixed lymphocyte culture (MLC); and that a soluble low molecular weight factor may be involved in such EC-derived immunoregulation. In addition, the erythroid cell-derived suppressor factor (ESF) was found to be capable of effectively reducing the allergen-driven proliferation of peripheral blood mononuclear cells (PBMC) isolated from allergic patients.

Bone Marrow Cells in Suppressing Leukemic Cell Growth.

In this paper we review our experimental findings concerning the capacity of bone marrow cells (BMC) to control leukemic cell growth. It has been shown that the cells isolated from normal bone marrow can provide dose dependent suppression of the proliferative activity of leukemic cells in vitro. BMC cytostatic effect is antigen non-specific and does not associate with cell death.