Effect of mycophenolate mofetil on progression of interstitial fibrosis and tubular atrophy after kidney transplantation: a retrospective study.

Objectives: Chronic transplant dysfunction after kidney transplantation is a major reason of kidney graft loss and is caused by immunological and non-immunological factors. There is evidence that mycophenolate mofetil (MMF) may exert a positive effect on renal damage in addition to immunosuppression, by its direct antifibrotic properties. The aim of our study was to retrospectively investigate the role of MMF doses on progression of chronic allograft dysfunction and fibrosis and tubular atrophy (IF/TA).

[Bloodstream infections after liver and hematopoietic stem cell transplantation].

The aim of this retrospective study was to evaluate and compare the incidence, timing and etiology of bloodstream infections (BSIs) in patients treated with liver-(LT) or hematopoietic stem cell transplantation (HSCT) in a single institution. We evaluated 280 consecutive transplantations over a period of 34 months. Our results demonstrated 84 episodes of BSIs (47 in LT patients and 37 in HSCT patients) at a median of 28 days post-transplantation.

Prognostic performance of the Simplified Acute Physiology Score II in major Croatian hospitals: a prospective multicenter study.

Aim: To perform an external validation of the original Simplified Acute Physiology Score II (SAPS II) system and to assess its performance in a selected group of patients in major Croatian hospitals.

Methods: A prospective, multicenter study was conducted in five university hospitals and one general hospital during a six-month period between November 1, 2007 and May 1, 2008. Standardized hospital mortality ratio (SMR) was calculated from the mean predicted mortality of all the 2756 patients and the actual mortality for the same group of patients.

Spinal anesthesia at the L2-3 and L3-4 levels: comparison of analgesia and hemodynamic response.

Aim of this study was to evaluate level of analgesia and hemodynamic response to spinal anesthesia obtained by administering 15 mg 0.5% isobaric bupivacaine at L2-3 vs. L3-4 interspace for inguinal herniorrhaphy, since studies comparing analgesia and hemodynamic response at the L2-3 vs.

Parvovirus B 19 (PVB19) induced pure red cell aplasia (PRCA) in immunocompromised patient after liver transplantation.

Presented here is a case of human parvovirus B19 (PVB19) induced pure red-cell aplasia (PRCA) in immunocompromised patient after orthotopic liver transplantation (OLT). PVB19 is a small, single-stranded DNA whose target cell is the erythroid progenitor in bone marrow. Manifestations of PVB19 infection vary with the immunologic status of the patient, ranging from asymptomatic to severe infections and PRCA.

Epitheloid hemangioendothelioma in patient with liver transplantation.

Malignant hepatic epithelioid hemangioendothelioma (HEH) is a rare malignant tumor of vascular origin with unknown aetiology and a variable natural course. At the time of diagnosis, most patients present with multifocal tumours lesions that involve both liver lobes. From the therapeutic aspect, liver resection (LRx), liver transplantation (LTx), chemotherapy, radiotherapy, and/or immunotherapy have been used in the treatment of patients with HEH.

[The role of nutrition support in acute pancreatitis].

Nutritional support has been recognised as an important part in the treatment of acute pancreatitis. Acute pancreatitis varies in its severity from mild inflammatory process within pancreatic tissue to severe necrotic pancreatitis with involvement of regional tissues and remote organs leading to the multi organ dysfunction syndrome. Acute pancreatitis results in hypermetabolic, highly catabolic state and negative nitrogen balance, the degree of which is directly related to the severity of the disease and high mortality (up to 40%).

[Minimally invasive aortic surgery (MIAS)].

In this study we presented benefits of minimally invasive approach (MIAS) for treating abdominal aortic aneurysm (AAA) and aortoiliac occlusive disease (AIOD). MIAS technique consisted of minilaparotomy approach using incision length of 7-12 cm, intraabdominal small bowel retraction and standard aortic reconstruction with terminoterminal anastomosis or aortobifemoral bypass. Between December 2004 and January 2007 we perfomed 32 repairs for AAA and AIOD using MIAS technique.