Publications by authors named "Denis Cmunt"
Article Synopsis
- The NKR-P1 receptor plays an important role in immune responses and cancer, requiring a detailed understanding of its interactions with the LLT1 ligand.
- Researchers have mapped the crystal structures of the NKR-P1 and its complex with LLT1, revealing that NKR-P1 forms unexpected homodimers that can bind two LLT1 molecules simultaneously.
- The study shows that only binding to both interfaces of LLT1 is needed for effective inhibitory signaling, contributing to a model of how these protein interactions facilitate immune synapse formation despite weak ligand-receptor affinities.
Targeted cancer immunotherapy is a promising tool for restoring immune surveillance and eradicating cancer cells. Hydrophilic polymers modified with coiled coil peptide tags can be used as universal carriers designed for cell-specific delivery of such biologically active proteins. Here, we describe the preparation of pHPMA-based copolymer conjugated with immunologically active protein B7-H6 via complementary coiled coil VAALEKE (peptide E) and VAALKEK (peptide K) sequences.
View Article and Find Full Text PDFThe existence of programmed cell death in has been reported for many years. Glucose induces the death of in the absence of additional nutrients within a few hours, and the absence of active potassium uptake makes cells highly sensitive to this process. cells possess two transporters, Trk1 and Trk2, which ensure a high intracellular concentration of potassium, necessary for many physiological processes.
View Article and Find Full Text PDFNa(+)/H(+) antiporters may recognize all alkali-metal cations as substrates but may transport them selectively. Plasma-membrane Zygosaccharomyces rouxii Sod2-22 antiporter exports Na(+) and Li(+), but not K(+). The molecular basis of this selectivity is unknown.
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