Publications by authors named "Denis A Lagutkin"
Biology (Basel)
August 2021
Article Synopsis
- * The article explores how factors like inflammation, poor lung function, and blood clots lead to acidosis, creating a harmful cycle that worsens oxygen levels and patient health.
- * It emphasizes that maintaining normal blood pH could be a crucial strategy for treating COVID-19, given its role in immune response and potential for causing a "cytokine storm."
Microorganisms
August 2021
Article Synopsis
- The study investigates the virulence of two clinical strains of the Beijing genotype associated with drug-resistant tuberculosis in C57BL/6 mice, highlighting their correlation to global health issues.
- Strains 267/47 (pre-XDR) and 120/26 (MDR) showed differing survival rates in infected mice, with 10% and 40% survival, respectively, compared to 70% for the H37Rv strain.
- Comparison of immune responses revealed significant differences in cytokine gene expression, particularly with downregulated pro-inflammatory and anti-inflammatory genes in mice infected with the more virulent strain 267/47.
Article Synopsis
- * Results showed that while gender had no impact, the age of donors significantly influenced the O_hyper parameter, indicating a correlation between RBC age and their properties.
- * The research found that younger RBCs (L-fraction) produced more oxidants yet had higher levels of reduced thiols compared to older RBCs, prompting a recommendation for age-stratified reference values in diagnosing RBC-related conditions.
