Background And Purpose: Interpenetrating polymer network (IPN) hydrogels are an adaptable category of materials, exhibiting remarkable promise for various biological applications due to their distinctive structural and functional attributes. This review delves into the synthesis of IPN hydrogels through both physical and chemical methodologies, elucidating how these techniques allow for precise tailoring of mechanical properties, swelling behaviour, and biocompatibility.
Experimental Approach: We conducted an extensive literature review by searching well-established online research databases for articles published since 2009 to gather comprehensive data on IPN hydrogels.
Background And Purpose: In this study, we examined the impact of Zn-bioMOF structures on the physical and chemical characteristics as well as the biocompatibility of a matrix composed of semi-interpenetrating polymeric networks (semi-IPN) made from collagen and L-tyrosine-based polyelectrolytes.
Experimental Approach: We hydrothermally synthesized L-1, ZIF-8H Zn-bioMOFs, and the Zn-(L-His) complex, utilizing L-histidine, a bioactive amino acid, as a ligand. These metal-organic compounds primarily enhance the mechanical properties of the novel composite hydrogels through physical interactions such as hydrogen bonds and dipolar interactions.
In this work, the xylose conversion and the selectivity to furfural were assessed over mesoporous sulfonic silica SBA-15-(X)SOH catalysts doped with metal ions (X = Al(iii), Ti(iv) or Zr(iv)). The type and amount of acid sites were analyzed by adsorption of pivalonitrile. The SBA-15-(X)SOH materials show Lewis acid sites (LAS) and two types of Brønsted acid sites (BAS) with different strengths.
View Article and Find Full Text PDFBiopolymers
June 2023
In this work, hydrogels based on semi-interpenetrating polymeric networks (semi-IPN) based on collagen-polyurethane-alginate were studied physicochemically and from different approaches for biomedical application. It was determined that the matrices in the hydrogel state are crosslinked by the formation of urea and amide bonds between the biopolymer chains and the polyurethane crosslinker. The increment in alginate content (0-40 wt%) significantly increases the swelling capacity, generating semi-crystalline granular structures with improved storage modulus and resistance to thermal, hydrolytic, and proteolytic degradation.
View Article and Find Full Text PDFBiomed Mater
April 2023
The design of hydrogels based on natural polymers that have modulation of antibacterial capacity, ideal performance in release capacity of encapsulated drugs, and desired bioactivity for applications in wound healing represents a modern trend in biomaterials. In this work, novel hydrogels of semi-interpenetrating polymeric networks based on collagen and xanthan gum (XG) were investigated. The linear chains of XG can semi-interpenetrate inside to matrix of crosslinked collagen with polyurethane under physiological conditions, generating amorphous surfaces with fibrillar-granular reliefs that have accelerated gelation time (about 15 min), super water absorption (up to 3100%) and high inhibition capacity of pathogenic bacteria such as(up to 100% compared to amoxicillin at 20 ppm).
View Article and Find Full Text PDFIn this work, we report the synthesis of a biobased hydrogel comprised of collagen, chitosan, and polyurethane for the removal of textile dyes. The adsorption capacity of this hydrogel was improved by adding a magnesium metal-organic framework to the semi-interpenetrating polymer matrix yielding a composite hydrogel. Removal of Bismarck Brown and Congo red was studied, and the experimental results fit Freundlich's model.
View Article and Find Full Text PDFMetal-organic frameworks (MOFs) are microporous materials with high potential for biomedical applications. They are useful as drug delivery systems, antibacterials, and biosensors. Recently, composite materials comprised of polymer matrixes and MOFs have gained relevance in the biomedical field due to their high potential as materials to accelerate wound healing.
View Article and Find Full Text PDFDeveloping new approaches to improve the swelling, degradation rate, and mechanical properties of alginate hydrogels without compromising their biocompatibility for biomedical applications represents a potential area of research. In this work, the generation of interpenetrated networks (IPN) comprised from alginate-polyurethane in an aqueous medium is proposed to design hydrogels with tailored properties for biomedical applications. Aqueous polyurethane (PU) dispersions can crosslink and interpenetrate alginate chains, forming amide bonds that allow the structure and water absorption capacity of these novel hydrogels to be regulated.
View Article and Find Full Text PDFCurrently, the control of the properties of collagen based hydrogels represents a promising area of research to develop novel materials for biomedical applications. The crosslinking of the collagen with trifunctional polyurethane (PU) allows a hybrid matrix to be formed by improving the coupling with exogenous polymeric chains to generate innovative semi-interpenetrated network (semi-IPN) hydrogels. The incorporation of polyacrylate (PA) within a hybrid matrix of collagen-PU allows to regulate the structure and physicochemical properties such as polymerization rate, physicochemical crosslinking, thermal stability, storage module and swelling/degradation behavior of the 3D matrices in the hydrogel state, also exhibiting modulation of their in vitro biocompatibility properties.
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