Publications by authors named "Dengzhi Zhao"
[Clinical features and genetic analysis of two Chinese pedigrees affected with Joubert syndrome].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
January 2023
Objective: To explore the clinical characteristics and genetic basis of two Chinese pedigrees affected with Joubert syndrome.
Methods: Clinical data of the two pedigrees was collected. Genomic DNA was extracted from peripheral blood samples and subjected to high-throughput sequencing.
CYP3A4*1G regulates CYP3A4 intron 10 enhancer and promoter activity in an allelic-dependent manner.
Int J Clin Pharmacol Ther
August 2015
Objective: CYP3A4*1G (G > A) in human CYP3A4 intron 10 is associated with therapeutic effects of CYP3A4-metabolized drugs. The aim of this study was to predict its function in the regulation of CYP3A4 expression.
Methods: Functional analysis of the CYP3A4*1G allele was performed using bioinformatic methods and enhancer or promoter reporter assays in HepG2 cells.
Article Synopsis
- The study explores how gender influences the pharmacokinetics (how the body processes drugs) of simvastatin lactone and its active form, simvastatin hydroxy acid, in healthy Han Chinese volunteers.
- Results show no significant gender differences in the pharmacokinetics of simvastatin lactone, but females had higher peak plasma concentrations of simvastatin hydroxy acid compared to males.
- The findings suggest that while simvastatin lactone's effects are similar for both genders, women may be at a higher risk for side effects from simvastatin hydroxy acid due to increased plasma levels.