MiR-106b-5p regulates esophageal squamous cell carcinoma progression by binding to HPGD.

Background: Several studies have documented the key role of microRNAs (miRNAs) in esophageal squamous cell carcinoma (ESCC). Although the expression of the 15-hydroxyprostaglandin dehydrogenase (HPGD) gene and miR-106b-5p are reportedly linked to cancer progression, their underlying mechanisms in ESCC remain unclear.

Methods: mRNA and miRNA expression in ESCC tissues and cells were analyzed using RT-qPCR.

MicroRNA-499-5p targets SIRT1 to aggravate lipopolysaccharide-induced acute lung injury.

Acute lung injury (ALI) is a life-threatening disease without effective and specific therapeutic strategies except the life-supporting treatments. Inflammation and oxidative stress are essential for the progression of ALI. MicroRNA-499-5p () has multiple pathophysiological actions; however, its function and mechanisms in ALI remain elusive.

Factors associated with the costs of hospitalization after esophagectomy: a retrospective observational study at a three-tertiary cancer hospital in China.

Background: Esophageal cancer represents a major health threat in China. Esophagectomy is the standard treatment for respectable esophageal cancer. This study aimed to investigate the costs of hospitalization in esophageal cancer patients undergoing esophagectomy, and to analyze the factors influencing these costs.

MicroRNA-217 modulates inflammation, oxidative stress, and lung injury in septic mice via SIRT1.

Inflammation and oxidative stress contribute to the initiation and progression of septic lung injury. MicroRNA-217 () is proved to be involved in controlling inflammatory response and oxidative stress, yet its role and underlying mechanism in the pathogenesis of septic lung injury remain elusive. Caecal ligation and puncture surgery were performed to generate sepsis and mice were kept for 12 h to imitate septic lung injury.

The Improved Mediastinal Drainage Strategy for the Enhanced Recovery System After Esophagectomy.

Background: The improved drainage strategy was the transperitoneal placement of a single mediastinal drainage tube after esophagectomy. This study aimed to explore its effect on the incidence of postoperative complications, pain scores, and hospital stay.

Methods: Data from 108 patients who underwent minimally invasive esophagectomy were retrospectively analyzed.

MicroRNA-326 prevents sepsis-induced acute lung injury via targeting TLR4.

Unrestrained inflammation provokes oxidative stress and contributes to the development of sepsis-induced acute lung injury (ALI). MicroRNA-326 () is originally identified as an autoimmunity-associated microRNA, yet its role and potential molecular basis in sepsis-induced ALI remain unclear. Herein, we found that was downregulated in murine lungs and macrophages upon lipopolysaccharide (LPS) stimulation.