The underlying regulatory mechanisms of colorectal carcinoma by combining Vitexin and Aspirin: based on systems biology, molecular docking, molecular dynamics simulation, and study.

Introduction: Colorectal cancer (CRC) is a highly prevalent digestive system malignancy. Aspirin is currently one of the most promising chemopreventive agents for CRC, and the combination of aspirin and natural compounds helps to enhance the anticancer activity of aspirin. Natural flavonoids like vitexin have an anticancer activity focusing on colorectal carcinoma.

Comparative efficacy and adverse reactions of apatinib-chemotherapy combinations versus chemotherapy alone for treatment of advanced colorectal cancer: a meta-analysis of randomized controlled trials.

Objective: Apatinib mesylate is the first small-molecule anti-angiogenic agent that has been shown to be effective and well-tolerated for treatment of advanced gastric cancer, and has shown encouraging efficacy for treatment of advanced colorectal cancer (CRC). However, previous studies reported diverse efficacy and safety results of apatinib for treatment of advanced CRC. This meta-analysis aimed to compare the efficacy and safety of apatinib plus chemotherapy (trial group) versus chemotherapy alone (control group) for treatment of advanced CRC.

The study of otoendoscopic tympanoplasty (type I).

Background: With the development of otoendoscopic surgery technology and the update of equipment, more and more otoendoscopic tympanoplasty are carried out.

Objectives: To investigate application of otoendoscopic tympanoplasty.

Methods: Seventy-six patients with tympanic membrane perforation were randomly enrolled into otoendoscopic group (OP,  = 38) and microscope group (MP,  = 38).

Clinical effect of CO laser resection of the epiglottic cyst under micro-laryngoscope suspension.

Background: Epiglottic cysts are common diseases and have multiple morbidity, and traditional surgery causes intraoperative bleeding and postoperative recurrence.

Objective: To investigate the therapeutic effect of CO laser resection on epiglottic cyst when compared with traditional surgery.

Method: Eighty patients with epiglottic cysts were randomly enrolled into the CO laser group (44 patients) and the high-frequency electrocautery group (36 patients).

Deformable Object Tracking With Gated Fusion.

The tracking-by-detection framework receives growing attention through the integration with the convolutional neural networks (CNNs). Existing tracking-by-detection-based methods, however, fail to track objects with severe appearance variations. This is because the traditional convolutional operation is performed on fixed grids, and thus may not be able to find the correct response while the object is changing pose or under varying environmental conditions.