Publications by authors named "Dengliang Li"

Unlabelled: (), a facultative intracellular bacterium, is an important zoonotic pathogen that causes abscesses and pyogenic granulomas. The relationship between gut microbiota and host health or diseases has received increasing attention. However, the role of gut microbiota in the process of infection is still unclear.

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  • PRRSV is a significant threat to the global swine industry, and this study identifies Nitazoxanide (NTZ) as a strong inhibitor against the virus in both laboratory and live swine models.
  • High-Throughput Screening revealed 16 potential anti-PRRSV compounds, with NTZ showing notable effectiveness in reducing the virus's spread and associated health issues in pigs.
  • The study also discovered that Tizoxanide (TIZ), a metabolite of NTZ, enhances the sensitivity of the IFN-β pathway, hinting at its role in how NTZ fights the virus.
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Mycoplasmal pneumonia in sheep and goats usually result covert but huge economic losses in the sheep and goat industry. The disease is prevalent in various countries in Africa and Asia. Clinical manifestations in affected animals include anorexia, fever, and respiratory symptoms such as dyspnea, polypnea, cough, and nasal discharge.

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  • Contagious ecthyma (CE), caused by the orf virus, primarily affects sheep and goats, leading to significant economic losses for farmers due to livestock market value impacts.
  • Two strains of the orf virus, FX and LX, were isolated from locations in China, showing distinct genetic variations and clustering into main domestic types, with significant viral populations observed mostly in India and China between 2007 and 2018.
  • The study highlights key genes of the virus with a focus on their evolutionary patterns and potential for vaccine development, as some viral epitopes were predicted for further testing.
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As essential transfer carriers for cell-to-cell communication and genetic material, exosomes carry microRNAs that participate in the regulation of various biological processes. MicroRNAs are a type of single-stranded noncoding RNA that bind to specific target gene mRNAs to degrade or inhibit their translation, thereby regulating target gene expression. Although it is known that a variety of microRNAs are involved in the viral infection process, there are few reports on specific microRNAs involved in porcine epidemic diarrhea virus (PEDV) infection.

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Cats infected with feline calicivirus (FCV) often display oral ulcers and inflammation of the upper respiratory tract, which can lead to death in severe cases. Antiviral therapy is one of the most effective ways to control FCV infection. Natural compounds in Chinese herbal medicines and medicinal plants provide abundant resources for research on antiviral drugs.

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Background: Feline calicivirus (FCV) is a common and highly prevalent pathogen causing upper respiratory diseases in kittens and felines in recent years. Due to the substantial genetic variability of the viral genes, existing vaccines cannot provide complete protection. Therefore, research on FCV antiviral drugs has received much attention.

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Feline calicivirus (FCV) is a highly contagious pathogen that causes acute upper respiratory infections and oral disease in cats, thus seriously endangering feline health. Recently, there have been outbreaks of particularly virulent variant strains of FCV, which can cause both acute symptoms and fatal systemic disease. The discovery of effective antiviral agents to treat FCV infection is, therefore, gradually assuming increased importance.

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Feline calicivirus (FCV) causes upper respiratory tract infections in felines and threatens the health of wild and domestic felines. Clinically, specific drugs to treat FCV have not yet been developed. Here, IgG was extracted from inactivated FCV-immunized horse sera.

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