Publications by authors named "Dengli Wu"
Unraveling the molecular mechanism of aqueous extract of Sargentodoxa cuneata against ulcerative colitis from serum metabolomics and bioinformatics perspectives.
J Chromatogr B Analyt Technol Biomed Life Sci
December 2024
Article Synopsis
- - The aqueous extract of Sargentodoxa cuneata (AESc) shows promise as a treatment for ulcerative colitis (UC) in mice, improving overall health indicators and reducing disease severity.
- - A comprehensive analysis identified 3445 serum metabolites, with 64 specifically linked to AESc's effectiveness against UC, focusing on pathways like arachidonic acid metabolism and drug metabolism.
- - The study also highlighted potential therapeutic metabolites and core targets, suggesting that AESc achieves its benefits by correcting metabolic disturbances and influencing various immune and inflammatory pathways.
Background: Ulcerative colitis (UC) is a refractory disease worldwide. Liver injury can be found clinically with UC, and now, it is found that gut dysbiosis is an important mechanism in the pathogenesis of UC. has been used as a traditional Chinese medicine and is commonly used clinically for the treatment of UC.
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