Publications by authors named "Dengjian Qu"
Article Synopsis
- The growth of the recombinant human collagen market necessitates a design strategy to maintain its biological activity while improving its mechanical properties for hard tissue repair.
- The study used a combination of alkali hydrolysis and Schiff's base chemistry to create PLLA-rhCol composites, which preserved the benefits of rhCol-I and enhanced their suitability for bone implant applications.
- In tests, PLLA-rhCol significantly outperformed traditional PLLA implants in promoting bone repair and tissue engineering, showing promising results in vivo, particularly for critical-sized bone defects in rats.
Regulation of Osteogenic Differentiation of hBMSCs by the Overlay Angles of Bone Lamellae-like Matrices.
ACS Appl Mater Interfaces
October 2024
Oriented fibers in bone lamellae are recognized for their contribution to the anisotropic mechanical performance of the cortical bone. While increasing evidence highlights that such oriented fibers also exhibit osteogenic induction to preosteoblasts, little is known about the effect of the overlay angle between lamellae on the osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs). In this study, bone lamellae-like fibrous matrices composed of aligned core-shell [core: polycaprolactone (PCL)/type I collagen (Col I) + shell: Col I] nanofibers were seeded with human BMSCs (hBMSCs) and then laid over on each other layer-by-layer (L--L) at selected angles (0 or 45°) to form three-dimensional (3D) constructs.
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