Biomimetic Metal-Pyrimidine Nanoflowers: Enzyme Immobilization Platforms with Boosted Activity.

For the enzyme immobilization platform, enhancing enzyme activity retention while improving enzyme stability remains a challenge for sensitive sensing analysis. Herein, an in situ biomimetic immobilized enzyme carrier (metal-pyrimidine nanoflowers, MPNFs) synthesized by the coordination of DNA base derivative (2-aminopyrimidine) with Zn in the aqueous phase at room temperature is developed. The biocompatibility of 2-aminopyrimidine and the hydrophilicity and green synthetic conditions of MPNFs allows the immobilized enzymes to retain above 91.

3D VO-MoS/rGO nanocomposites with enhanced peroxidase mimicking activity for sensitive colorimetric determination of HO and glucose.

In this work, we reported a novel nanozyme (3D VO-MoS/rGO) by decorating MoS nano-flowers and VO nanoparticles on reduced graphene oxide (rGO). The 3D VO-MoS/rGO nanocomposites exhibited intrinsic peroxidase mimicking activity and catalyzed the oxidation of 3, 3', 5, 5'-tetramethylbenzidine (TMB) to produce a blue colored product in the presence of HO. Compared with horseradish peroxidase (HRP), 3D VO-MoS/rGO nanocomposites displayed high catalytic velocity (V) and affinity (K) for substrates (HO and TMB).