Hypocalcemia Event Associated with Denosumab: A Real-World Study from FDA Adverse Event Reporting System (FAERS) Database.

Background And Objective: Denosumab is widely used for osteoporosis and cancer treatment. However, hypocalcemia induced by denosumab is a frequent adverse event. The objective of this study is to comprehensively investigate the safety signals and the occurrence of hypocalcemia in real-world patient cases reported through the Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS).

Construction of hollow sphere MnO with abundant oxygen vacancy for accelerating VOCs degradation: Investigation through operando spectroscopycombined with on-line mass spectrometry.

To clarify the key role of oxygen vacancy defects on enhancing the oxidative activity of the catalysts, metal-organic frameworks (MOFs) derived MnO catalysts with different morphologies and oxygen vacancy defects were successfully prepared using a facile in-situ self-assembly strategy with different alkali moderators. The obtained morphologies included three-dimensional (3D) triangular cone stacked MnO hollow sphere (MnO-H) and 3D nanoparticle stacked MnO nanosphere (MnO-N). Compared to MnO-N, MnO-H exhibited higher activity for the oxidation of toluene (T = 226 °C).

Tuning the Metal-Support Interaction by Modulating CeO Oxygen Vacancies to Enhance the Toluene Oxidation Activity of Pt/CeO Catalysts.

In this research, a range of Pt/CeO catalysts featuring varying Pt-O-Ce bond contents were developed by modulating the oxygen vacancies of the CeO support for toluene abatement. The Pt/CeO-HA catalyst generated a maximum quantity of Pt-O-Ce bonds (possessed the strongest metal-support interaction), as evidenced by the visible Raman results, which demonstrated outstanding toluene catalytic performance. Additionally, the UV Raman results revealed that the strong metal-support interaction stimulated a substantial increase in oxygen vacancies, which could facilitate the activation of gaseous oxygen to generate abundant reactive oxygen species accumulated on the Pt/CeO-HA catalyst surface, a conclusion supported by the H-TPR, XPS, and toluene-TPSR results.

Inflammatory immunity and bacteriological perspectives: A new direction for copper treatment of sepsis.

Copper is an essential trace element for all aerobic organisms because of its unique biological functions. In recent years, researchers have discovered that copper can induce cell death through various regulatory mechanisms, thereby inducing inflammation. Efforts have also been made to alter the chemical structure of copper to achieve either anticancer or anti-inflammatory effects.

Electrospun Ce-Mn oxide as an efficient catalyst for soot combustion: Ce-Mn synergy, soot-catalyst contact, and catalytic oxidation mechanism.

Increasing the contact efficiency and improving the intrinsic activity are two effective strategies to obtain efficient catalysts for soot combustion. Herein, the electrospinning method is used to synthesize fiber-like Ce-Mn oxide with a strong synergistic effect. The slow combustion of PVP in precursors and highly soluble manganese acetate in spinning solution facilitates the formation of fibrous Ce-Mn oxides.

In-situ atmosphere thermal pyrolysis of spindle-like Ce(OH)CO to fabricate Pt/CeO catalysts: Enhancing Pt-O-Ce bond intensity and boosting toluene degradation.

In this work, a series of spindle-like CeO supports with different contents of surface oxygen vacancies were fabricated by an in-situ atmosphere thermal pyrolysis method. Due to the unique surface physicochemical properties of the modified CeO supports, the interaction between Pt and CeO can be regulated during the synthesis of the Pt/CeO catalyst. The abundant oxygen vacancies on the CeO support could preferentially trap Pt ions in solution during the Pt impregnation process and enhance the Pt-CeO interaction in the subsequent reduction process, which results in the strongest Pt-O-Ce bonds formed on the PCH catalysts successfully (0.

Morphology-activity correlation of electrospun CeO for toluene catalytic combustion.

Herein, CeO catalysts with nanotube, nanobelt, and wire-in-nanotube morphologies were successfully fabricated by a facile single spinneret electrospinning technique. And catalytic activity of these electrospun CeO nanomaterials were evaluated by toluene catalytic combustion reaction. Among the three morphologies of CeO catalysts, CeO nanobelt (CeO-NB) presented the best toluene catalytic combustion performance (T = 230 °C) at WHSV = 60,000 mL g h, also exhibited the lowest activation energy (E = 80.

Hemocyte Changes During Immune Melanization in Infected with .

Hemolymph melanization is a conserved immune response in insects and other arthropods. However, the physiological process of the hemolymph system in the melanization response is hardly studied. Here, alterations of hemocytes in immune melanization were observed by infection in .

Leaf-like Co-ZIF-L derivatives embedded on CoAlO/Ni foam from hydrotalcites as monolithic catalysts for toluene abatement.

Herein, a series of distinctively monolithic catalysts were first synthesized by decorating leaf-like Co-ZIF-L derivatives on CoAlO coral-like microspheres from CoAl layered double hydroxides (LDHs), which were coated on three-dimensional porous Ni foam. As a proof of concept application, toluene was chosen as a probe molecule to evaluate their catalytic performances over the as-synthesized catalysts. As a result, the L-12 sample derived from CoAlO@Co-Co LDHs displayed an excellent catalytic performance, cycling stability and long-term stability for toluene oxidation (T = 272 °C, 33 °C lower than that of CoAlO sample), where leaf-like Co-ZIF-L served as a sacrificial template to synthesize Co-Co LDHs.

Inhibition of Ep3 attenuates migration and promotes apoptosis of non-small cell lung cancer cells via suppression of TGF-β/Smad signaling.

Non-small cell lung cancer (NSCLC) is the most common cause of cancer-associated mortality worldwide. Prostaglandin E2 (PGE2) regulates various biological processes, including invasion, proliferation and apoptosis. E-prostanoid 3 (Ep3) is a PGE2 receptor, and the functional role of Ep3 in the progression of NSCLC remains unresolved.

Two dopamine D2-like receptor genes from the silkworm (Bombyx mori) and their evolutionary history in metazoan.

Dopamine is widely distributed in metazoans and is implicated in many physiological functions. Dopaminergic signaling is mediated through two classes of dopamine receptors, D1-like and D2-like. Phylogeny analysis reveals that, the dopamine receptors probably appeared ahead of the cnidarian divergence, two distinct classes of dopamine receptors likely formed prior to the separation of deuterostomes and protostomes, and INDRs probably split from its ancestor before the emergence of nematodes.

[In vitro observation of haemolymph melanization and melanin-related biosynthesis enzyme genes in silkworm, Bombyx mori].

The observation statistics suggested that the haemolymph melanization speed of larvae became fast and the growth inhibition of Escherichia coli was strong as the quantities of feeding on mulberry leaves increased. The RT-PCR result showed that the mRNA expressions of melanin biosynthesis enzyme BmTan, BmPo-1, BmYellow-f and BmDdc were high in the haemolyph of 5 L 3 d larvae. The qPCR analysis showed Bmtan, Bmddc, Bmyellow, Bmebony and Bmblack, especially Bmddc expression were significantly higher in black disease larvae than in normal larvae.

Future events are far away: exploring the distance-on-distance effect.

Four dimensions of psychological distance (temporal, social, spatial, and probabilistic) have been widely studied. This research examines the distance-on-distance effect where an event that is close or distal along one dimension of psychological distance will be judged to be close or distal along other dimensions. For example, individuals will perceive greater likelihood to win a lottery (probabilistic distance) if they sit closer to the prize (spatial distance).

Knockdown of MDR1 increases the sensitivity to adriamycin in drug resistant gastric cancer cells.

Gastric cancer is one of the most frequently occurring malignancies in the world. Development of multiple drug resistance (MDR) to chemotherapy is known as the major cause of treatment failure for gastric cancer. Multiple drug resistance 1/P-glycoprotein (MDR1/p-gp) contributes to drug resistance via ATP-dependent drug efflux pumps and is overexpressed in many solid tumors including gastric cancer.