Publications by authors named "DengZhuo Chen"
Background: Existing cohort studies show no association between insulin use and cancers of the digestive system, while numerous meta-analyses suggest that insulin use increases the risk of digestive system tumours. This study uses two-sample Mendelian randomization (MR) to further investigate the causal relationship between the two.
Methods: We selected single nucleotide polymorphisms (SNPs) strongly associated with insulin use as instrumental variables and used aggregated statistics on digestive system neoplasms as the outcome event.
Article Synopsis
- The study investigates risk factors for postoperative complications in patients undergoing cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC).
- A meta-analysis of 15 articles involving 4021 patients found that risk factors such as sex, elevated peritoneal cancer index, longer surgery duration, and smoking habits are associated with complications, while factors like BMI and age showed no significant impact.
- The findings aim to aid clinicians in reducing postoperative complications and improving treatment decisions for cancer patients undergoing this combined therapy.