Local injection to sciatic nerve of dexmedetomidine reduces pain behaviors, SGCs activation, NGF expression and sympathetic sprouting in CCI rats.

Neuropathic pain has become an intractable health threat, with its profound effect on quality of life. Dorsal root ganglia (DRG) is evidenced to play a crucial role in neuropathic pain. The peripheral nociceptive afferents seem to be essential not only to initiate the process of neuropathic pain, but also to maintain and modulate it.

The effect of sevoflurane on the cognitive function of rats and its association with the inhibition of synaptic transmission.

To observe the effects of different concentrations of sevoflurane on synaptotagmin 1 (Syt1) expression, synaptic long term depression (LTD), and paired pulse depression (PPD) in the rat hippocampus as well as to investigate the association between these effects and the cognitive function of rats. A total of 24 male Sprague-Dawley (SD) rats were selected and randomly divided into 3 groups: the control group (group A), which inhaled air; group B, which inhaled 0.65 minimum alveolar concentration (MAC) sevoflurane for 2 h; and group C, which inhaled 1.

The effect of sevoflurane on the expression of M1 acetylcholine receptor in the hippocampus and cognitive function of aged rats.

Our aim is to investigate the effect of 1.5 and 3.0% sevoflurane on the expression of M(1) acetylcholine receptor (mAChR M(1)) in the hippocampus and the cognitive function of aged rats.

The effect of sevoflurane anesthesia on cognitive function and the expression of Insulin-like Growth Factor-1 in CA1 region of hippocampus in old rats.

To investigate the effects of sevoflurane on cognitive function in old Sprague-Dawley (SD) rats and the expression of insulin-like growth factor-1 (IGF-1) in CA1 region of hippocampus. Forty Sprague-Dawley rats of 12 months old were randomly divided into five groups: the normal control group; 1.5% sevoflurane I group (be tested after received 1.

DFT calculations on the structural stability and infrared spectroscopy of endohedral metallofullerenes.

Endohedral metallofullerenes M@C(24) (M = Li(0/+), Na(0/+), K(0/+), Be(0/2+), Mg(0/2+) and Ca(0/2+)) with different spin configurations have been systematically investigated using the hybrid DFT-B3PW91 functional in conjunction with 6-31 G(d) basis sets. Our theoretical studies show that Li@C(24), Be@C(24), Be(2+)@C(24), and Mg(2+)@C(24) are energetically favorable. In these endohedral metallofullerenes, only the encapsulated Be and Ca atoms can donate the electrons to the cage.