Pathway cross-talk network analysis identifies critical pathways in neonatal sepsis.

Background: Despite advances in neonatal care, sepsis remains a major cause of morbidity and mortality in neonates worldwide. Pathway cross-talk analysis might contribute to the inference of the driving forces in bacterial sepsis and facilitate a better understanding of underlying pathogenesis of neonatal sepsis.

Objective: This study aimed to explore the critical pathways associated with the progression of neonatal sepsis by the pathway cross-talk analysis.