Characterization of rhizosphere bacterial communities in oilseed rape cultivars with different susceptibility to infection.

Rhizosphere microbiomes are constantly mobilized during plant-pathogen interactions, and this, in turn, affects their interactions. However, few studies have examined the activities of rhizosphere microbiomes in plants with different susceptibilities to soil-borne pathogens, especially those that cause clubroot disease. In this study, we compared the rhizosphere bacterial community in response to infection of among the four different clubroot susceptibility cultivars of oilseed rape ().

SVTSR: image super-resolution using scattering vision transformer.

Vision transformers have garnered substantial attention and attained impressive performance in image super-resolution tasks. Nevertheless, these networks face challenges associated with attention complexity and the effective capture of intricate, fine-grained details within images. These hurdles impede the efficient and scalable deployment of transformer models for image super-resolution tasks in real-world applications.

Serotonin neurons integrate GABA and dopamine inputs to regulate meal initiation.

Obesity is a growing global health epidemic with limited orally administered therapeutics. Serotonin (5-HT) is one neurotransmitter which remains an excellent target for new weight-loss therapies, but a gap remains in understanding the mechanisms involved in 5-HT produced in the dorsal Raphe nucleus (DRN) and its involvement in meal initiation. Using an optogenetic feeding paradigm, we showed that the 5-HT➔arcuate nucleus (ARH) circuit plays a role in meal initiation.

Prolonged interval hypofractionated radiotherapy facilitates better antitumor immunity.

Purpose: To evaluate the impact of hypofractionated radiotherapy (Hypo-RT) with different interfraction intervals on tumor growth, immune response, and synergistic effects with anti-PD-1 immunotherapy.

Methods: The mouse MC38 colon cancer model was utilized. Various radiation regimens were designed to investigate the effects of fraction interval and fraction size on tumor growth, immune mobilization, and combination effects with anti-PD-1 immunotherapy.

Systemic air embolism associated with endoscopic retrograde cholangiopancreatography: A case report.

Background: Endoscopic retrograde cholangiopancreatography (ERCP) is a key procedure for diagnosing and treating biliary and pancreatic disorders. Although effective, it carries risks, including rare but severe complications such as air embolism.

Case Summary: We report a case of a 58-year-old man who developed extensive air embolism during ERCP.

Mechanistic Understanding of Long Duration Fast Charge Aqueous Zinc Batteries Using Physically Adsorbed Oligomers as Interphases.

Polymers have been used as additives in the liquid electrolytes typically used for secondary batteries that utilize metals as anode. Such additives are conventionally argued to improve long-term anode performance by suppressing morphological and hydrodynamic instabilities thought to be responsible for out-of-plane and dendritic metal deposition during battery charging. More recent studies have reported that the polymer additives provide even more fundamental mechanisms for stabilizing metal electrodeposition through their ability to regulate metal electrodeposit crystallography and, thereby, morphology.

Identification of an ionic mechanism for ERα-mediated rapid excitation in neurons.

The major female ovarian hormone, 17β-estradiol (E), can alter neuronal excitability within milliseconds to regulate a variety of physiological processes. Estrogen receptor-α (ERα), classically known as a nuclear receptor, exists as a membrane-bound receptor to mediate this rapid action of E, but the ionic mechanisms remain unclear. Here, we show that a membrane channel protein, chloride intracellular channel protein-1 (Clic1), can physically interact with ERα with a preference to the membrane-bound ERα.

Discovery of CZL-046 with an ()-3-Fluoropyrrolidin-2-one Scaffold as a p300 Bromodomain Inhibitor for the Treatment of Multiple Myeloma.

E1A binding protein (p300) is a promising therapeutic target for the treatment of cancer. Herein, we report the discovery of a series of novel inhibitors with an ()-3-fluoropyrrolidin-2-one scaffold targeting p300 bromodomain. The best compound (CZL-046) shows potent inhibitory activity of p300 bromodomain (IC = 3.

Screening of potential targets and small-molecule drugs related to lipid metabolism in ovarian cancer based on bioinformatics.

Background: about 70 % of ovarian cancer (OC) patients with postoperative chemotherapy relapse within 2-3 years due to drug resistance and metastasis, and the 5-year survival rate is only about 30 %. Lipid metabolism plays an important role in OC. We try to explore the potential targets and drugs related to lipid metabolism to provide clues for the treatment of OC.

Microbial succession in different years of pit mud from a distillery in Sichuan for fermentation.

Unlabelled: Microbial community and succession of 5-, 20-, and 50-year pit mud (PM) were uncovered in this study. The results showed that , and were dominant phyla in these PM samples. Interestingly, most sequences could not be classified into fungal taxa at the genus level by UNITE Database, the diversity and richness of bacteria in these PMs were higher than that of fungi.

Targeting the Cascade Amplification of Macrophage Colony-stimulating Factor to Alleviate the Immunosuppressive Effects Following Radiotherapy.

Radiotherapy (RT) serves as the primary treatment for solid tumors. Its potential to incite an immune response against tumors both locally and distally profoundly impacts clinical outcomes. However, RT may also promote the accumulation of immunosuppressive cytokines and immunosuppressive cells, greatly impeding the activation of antitumor immune responses and substantially limiting the effectiveness of RT.

Jamming is a first-order transition with quenched disorder in amorphous materials sheared by cyclic quasistatic deformations.

Jamming is an athermal transition between flowing and rigid states in amorphous systems such as granular matter, colloidal suspensions, complex fluids and cells. The jamming transition seems to display mixed aspects of a first-order transition, evidenced by a discontinuity in the coordination number, and a second-order transition, indicated by power-law scalings and diverging lengths. Here we demonstrate that jamming is a first-order transition with quenched disorder in cyclically sheared systems with quasistatic deformations, in two and three dimensions.

Identification and Validation of Prognostic Markers for Endometriosis-Associated Ovarian Cancer.

Growing evidence suggests that endometriosis (EMs) is a risk factor for endometriosis-associated ovarian cancer (EAOC). The aim was to identify and validate gene signatures associated with EMs that may serve as potential biomarkers for evaluating the prognosis of patients with EAOC. The data of EMs and control samples was obtained from GEO database.

Tissue characterization at an enhanced resolution across spatial omics platforms with deep generative model.

Recent advances in spatial omics have expanded the spectrum of profiled molecular categories beyond transcriptomics. However, many of these technologies are constrained by limited spatial resolution, hindering our ability to deeply characterize intricate tissue architectures. Existing computational methods primarily focus on the resolution enhancement of transcriptomics data, lacking the adaptability to address the emerging spatial omics technologies that profile various omics types.

Association between glycemia and multi-vessel lesion in participants undergoing coronary angiography: a cross-sectional study.

Background: This study aims to elucidate the association between glycemia and the occurrence of multi-vessel lesions in participants undergoing coronary angiography.

Methods: We analyzed 2,533 patients with coronary artery disease who underwent coronary angiography. Of these, 1,973 patients, identified by the endpoint of multi-vessel lesions, were examined using univariate and multivariate logistic regression analyses to determine the relationship between glycemia levels and multi-vessel lesion occurrence.

Impact of Hypertension Duration on the Cardiovascular Benefit of Intensive Blood Pressure Control.

Background: The optimal timing for initiating intensive systolic blood pressure (SBP) treatment remains unclear. While longer hypertension duration is positively associated with increased cardiovascular disease risk, it is unknown whether patients with prolonged hypertension can derive similar benefits from intensive SBP treatment.

Methods: From the STEP trial (Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients), 8442 participants with complete hypertension duration data were categorized by hypertension duration ≤5 years, 5 to 10 years, 10 to 15 years, and >15 years.

Solid-state polymer-particle hybrid electrolytes: Structure and electrochemical properties.

Solid-state electrolytes (SSEs) are challenged by complex interfacial chemistry and poor ion transport through the interfaces they form with battery electrodes. Here, we investigate a class of SSE composed of micrometer-sized lithium oxide (LiO) particles dispersed in a polymerizable 1,3-dioxolane (DOL) liquid. Ring-opening polymerization (ROP) of the DOL by Lewis acid salts inside a battery cell produces polymer-inorganic hybrid electrolytes with gradient properties on both the particle and battery cell length scales.

Characterization of the complete mitochondrial genome of Lendn. 1930 (Mucorales: Mucoraceae), isolated from the wine fermentation system.

Lendn. 1930 has been widely used in food fermentation; however, its mitochondrial genome characteristics are not well understood. In this study, the complete mitochondrial genome of was obtained, which was 61,400 bp in length with a GC content of 33%.