An Eight-CpG-based Methylation Classifier for Preoperative Discriminating Early and Advanced-Late Stage of Colorectal Cancer.

Aim: To develop and validate a CpG-based classifier for preoperative discrimination of early and advanced-late stage colorectal cancer (CRC).

Methods: We identified an epigenetic signature based on methylation status of multiple CpG sites (CpGs) from 372 subjects in The Cancer Genome Atlas (TCGA) CRC cohort, and an external cohort (GSE48684) with 64 subjects by LASSO regression algorithm. A classifier derived from the methylation signature was used to establish a multivariable logistic regression model to predict the advanced-late stage of CRC.

[Clinical and imaging features of thirty cases of paragonimiasis westermani].

Objective: To analyze the clinical manifestations and imaging characteristics of pulmonary and extra pulmonary paragonimiasis westermani.

Methods: A retrospective analysis was performed of 30 patients diagnosed by clinical features, laboratory serological tests and surgical pathology.

Results: The symptoms of the lung included mainly chest distress, fever, chest pain, cough and expectoration, and dyspnea.