Microstructure Abnormalities of Diffusion Tensor Imaging Measures in First-Episode, Treatment-Naïve Adolescents With Major Depressive Disorder: An Integrated AFQ and TBSS Study.

Purpose: Structural changes during depressive episodes in adolescents with major depressive disorder (MDD) remains unclear due to participant heterogeneity, illness chronicity, and medication confounders. This study aimed to explore white matter (WM) microstructural changes in first-episode, treatment-naïve adolescents with MDD using an integrated diffusion tensor imaging (DTI) approach.

Method: We recruited 66 subjects, including 37 adolescents with MDD and 29 healthy controls.

SPAC-Net: Rethinking Point Cloud Completion with Structural Prior.

Point cloud completion aims to infer a complete shape from its partial observation. Many approaches utilize a pure encoderdecoder paradigm in which complete shape can be directly predicted by shape priors learned from partial scans, however, these methods suffer from the loss of details inevitably due to the feature abstraction issues. In this paper, we propose a novel framework, termed SPAC-Net, that aims to rethink the completion task under the guidance of a new structural prior, we call it interface.

CFAP410 has a bimodular architecture with a conserved surface patch on its N-terminal leucine-rich repeat motif for binding interaction partners.

Cilia and flagella associated protein 410 (CFAP410) is a protein localized at the basal body of cilia/flagella and plays essential roles in ciliogenesis. Multiple single amino acid mutations in CFAP410 have been identified in patients. However, the molecular mechanism for how the mutations cause these disorders remains poorly understood due to a lack of high-resolution structures of the protein.

The research progress on effective connectivity in adolescent depression based on resting-state fMRI.

Introduction: The brain's spontaneous neural activity can be recorded during rest using resting state functional magnetic resonance imaging (rs-fMRI), and intricate brain functional networks and interaction patterns can be discovered through correlation analysis. As a crucial component of rs-fMRI analysis, effective connectivity analysis (EC) may provide a detailed description of the causal relationship and information flow between different brain areas. It has been very helpful in identifying anomalies in the brain activity of depressed teenagers.

Long noncoding RNA GDIL acts as a scaffold for CHAC1 and XRN2 to promote platinum resistance of colorectal cancer through inhibition of glutathione degradation.

Acquired resistance poses a significant obstacle to the effectiveness of platinum-based treatment for cancers. As the most abundant antioxidant, glutathione (GSH) enables cancer cell survival and chemoresistance, by scavenging excessive reactive oxygen species (ROS) induced by platinum. Therapeutic strategy targeting GSH synthesis has been developed, however, failed to produce desirable effects in preventing cancer progression.

Coupling Study of Fracture Propagation-Filtration-Seepage during Hydraulic Fracturing Assisted Oil Displacement in Offshore Low-Permeability Reservoirs.

Offshore low-permeability reservoirs are mainly composed of complex fault-block structures with poor physical properties, which makes establishing an effective displacement relationship particularly challenging. Hydraulic fracturing assisted oil displacement (HFAD) can effectively increase the oil production of a single well by creating fractures to replenish the producing energy. In this study, the Khristianovich-Geertsma-de Klerk (KGD) model is used to calculate the propagation of vertical fractures, and the flow tube method is used to calculate the two-phase oil-water flow in filtration and seepage.

Treponema denticola major surface protein (Msp): a key player in periodontal pathogenicity and immune evasion.

Treponema denticola, a bacterium that forms a "red complex" with Porphyromonas gingivalis and Tannerella forsythia, is associated with periodontitis, pulpitis, and other oral infections. The major surface protein (Msp) is a surface glycoprotein with a relatively well-established overall domain structure (N-terminal, central and C-terminal regions) and a controversial tertiary structure. As one of the key virulence factors of T.

Sensitive detection of formaldehyde a luminescent distorted EuL tetrahedral cage.

A distorted low-symmetry EuL tetrahedral cage was fabricated through the self-assembly of europium ions and -symmetric bowl-shaped ligands containing a phosphangulene core. X-ray crystallography confirmed its unique architecture, featuring significant structural distortion and solvent-accessible coordination sites. This cage showcases exceptional luminescence-based sensitivity for formaldehyde detection compared to other analogs, achieving an impressive detection limit of 19.

Efficacy and safety of once-weekly insulin versus once-daily insulin in patients with type 1 and type 2 diabetes mellitus: an updated meta-analysis of randomized controlled trials.

Background: This meta-analysis was performed to obtain a comprehensive overview of the differences between once-weekly basal insulin (including icodec and basal insulin Fc) and once-daily basal insulin (including glargine and degludec) in patients with type 1 and type 2 diabetes mellitus.

Methods: PubMed, EMBASE, and Cochrane Library were systematically searched for eligible studies up to 2 January 2024.

Results: A total of 12 studies were included, comprising 5,895 patients, with 3,104 (52.

LPM682000012, a Synthetic Neuroactive Steroid That Ameliorates Epileptic Seizures by Downregulating the /NF-κB Signaling Pathway.

Epilepsy is characterized by abnormal neuronal firing in the brain. Several therapeutic strategies exist for epilepsy; however, several patients remain poorly treated. Therefore, the development of effective treatments remains a high priority in the field.

Association of sleep quality with cognitive dysfunction in middle-aged and elderly adults: a cross-sectional study in China.

Objectives: Sleep is an indispensable part of human health, which can help us to restore physical strength, enhance immunity and maintain nervous system stability. The relationship between sleep quality and cognitive dysfunction is unclear, especially at the community population level. This study aims to explore the association between sleep quality and cognitive dysfunction.

Epidemic characteristics of measles and efforts to control measles infections in Zhejiang Province, China.

Objectives: Several countries have successfully eliminated measles, and China is making significant strides toward achieving this goal. This study focused on investigating the patterns of measles infections in Zhejiang Province, China, as well as control measures. The objective was to provide valuable insights that could contribute to the development of nationwide elimination strategies.

Demethylzeylasteral ameliorates podocyte damage in murine lupus by inhibiting inflammation and enhancing autophagy.

Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with multiorgan and tissue involvement. Lupus nephritis (LN), an inflammatory condition of the kidneys associated with SLE, represents a significant cause of morbidity and mortality in SLE patients. Current immunosuppressive therapies for LN have limited efficacy and can lead to significant side effects.

A Serological Survey of Measles and Rubella Antibodies among Different Age Groups in Eastern China.

Background: Measles and rubella are vaccine-preventable diseases targeted for elimination in most World Health Organization regions, and China is considered to have momentum towards measles elimination. Therefore, this study aimed to assess the population immunity levels against measles and rubella in Zhejiang Province in China in order to provide valuable insights for informing future public health measures and contributing to the ongoing global campaign against these diseases.

Materials And Methods: A cross-sectional serological survey was conducted in 2022.

Establishment of an RNA-based transient expression system in the green alga Chlamydomonas reinhardtii.

Chlamydomonas reinhardtii, a unicellular green alga, is a prominent model for green biotechnology and for studying organelles' function and biogenesis, such as chloroplasts and cilia. However, the stable expression of foreign genes from the nuclear genome in C. reinhardtii faces several limitations, including low expression levels and significant differences between clones due to genome position effects, epigenetic silencing, and time-consuming procedures.

Resolution of Peritoneal Dialysis-Associated Peritonitis From Weissella confusa Combined Gastric Hookworm Disease: A Case Report and Literature Review.

We reported a rare case of peritoneal dialysis-associated peritonitis caused by Weissella confusa. In this case, the symptoms of peritonitis were insidious and atypical, with only turbid peritoneal dialysis effluent and no fever or abdominal pain. The peritoneal dialysis effluent showed slightly elevated leukocytes (predominantly lymphocytes).

Fulvic acid application increases rice seedlings performance under low phosphorus stress.

Background: Fulvic acid enhances plant growth and interacts synergistically with phosphate fertilizer to alleviate the agricultural production problem of low phosphorus fertilizer utilization efficiency. However, the underlying mechanism of its action remains poorly understood. In this study, we investigated the impact of fulvic acid application with varying concentrations (0, 40, 60, 80 and 120 mg/L) on rice performance in plants grown in a hydroponic system subjected to low phosphorus stress.

EasyNAT Malaria: a simple, rapid method to detect species using cross-priming amplification technology.

Unlabelled: Malaria infection remains a serious threat to human health worldwide. Rapid and accurate detection technology is crucial for preventing malaria transmission and minimizing damage. We aimed to establish and validate a new rapid molecular detection method for malaria, called EasyNAT Malaria Assay, targeting , , , and .

An alternative method for inferring Pandy's test using cerebrospinal fluid total protein.

Background: Pandy's test is used to assess the globulin level in cerebrospinal fluid (CSF). As a semi-quantitative manual method, the practicality and clinical value of Pandy's test has been challenged.

Objective: We tend to summarize the relationship between CSF total protein (CSF-TP) quantification and Pandy's results, providing a formula to estimate Pandy's results merely by CSF-TP value.

Coagulation and fibrinolytic markers offer utility when distinguishing between benign and malignant gallbladder tumors: A cross-sectional study.

Background: The metabolic or proliferative abnormalities that are characteristic of tumor cells can lead to abnormal fibrinolysis or coagulation system activity, with certain tumors exhibiting hypercoagulability or existing in a fibrinolytic state. However, the utility of biomarkers of coagulation and fibrinolysis when seeking to differentiate between benign gallbladder disease and malignant gallbladder tumors remains uncertain.

Methods: This study included a total of 81 patients with benign gallbladder polyps and 94 patients with malignant gallbladder tumors.

Direct targeting of S100A9 with Icariin counteracted acetaminophen‑induced hepatotoxicity.

Acetaminophen (APAP) is a widely used antipyretic and analgesic medication, but its overdose can induce acute liver failure with lack of effective therapies. Icariin is a bioactive compound derived from the herb Epimedium that displays hepatoprotective activities. Here, we explored the protective effects and mechanism of icariin on APAP-induced hepatotoxicity.