MicroRNA-429 overexpression overcomes imatinib resistance of glioma cells by negatively regulating lysophosphatidic acid receptor 1.

Background: Glioma is one of the most aggressive and lethal malignancies in central nervous system. It has been reported that miR-429 is declined in glioma and functions as a tumor suppressor. Nonetheless, the potential role of miR-429 in drug resistance of glioma is still ambiguous.

Alginate Oligosaccharides Enhance Antioxidant Status and Intestinal Health by Modulating the Gut Microbiota in Weaned Piglets.

Alginate oligosaccharides (AOSs), which are an attractive feed additive for animal production, exhibit pleiotropic bioactivities. In the present study, we investigated graded doses of AOS-mediated alterations in the physiological responses of piglets by determining the intestinal architecture, barrier function, and microbiota. A total of 144 weaned piglets were allocated into four dietary treatments in a completely random design, which included a control diet (CON) and three treated diets formulated with 250 mg/kg (AOS250), 500 mg/kg (AOS500), and 1000 mg/kg AOS (AOS1000), respectively.

Millimeter-wave over fiber integrated sensing and communication system using self-coherent OFDM.

Orthogonal frequency-division multiplexing (OFDM) waveform is highly preferred as a dual-function candidate for integrated sensing and communication (ISAC) systems. However, the sensitivity to both carrier frequency offset (CFO) and phase noise greatly impedes its applications in millimeter-wave ISAC systems. Here, we propose and experimentally demonstrate a photonic millimeter-wave ISAC system employing the virtual-carrier-aided self-coherent OFDM technique, wherein a digitally-generated local oscillator is transmitted along with the OFDM signal.

Effects of main active components of rosemary on growth performance, meat quality and lipid metabolism in finishing pigs.

Rosemary extracts have been widely used as feed additives in recent years. This study aimed to investigate the effects of rosmarinic acid (RA) and ursolic acid (UA), the main active components of rosemary, on growth performance, meat quality and lipid metabolism in finishing pigs. A total of 72 finishing pigs (Landrace; initial age of 150 d) were randomly divided into 3 treatments with 8 replicates of 3 pigs each, and fed a basal diet or diet containing 500 mg/kg of RA or UA.

An gene missense variant in a Chinese Tujia ethnic family with genetic epilepsy with febrile seizures plus.

Genetic epilepsy with febrile seizures plus (GEFSP) is a familial epileptic syndrome that is genetically heterogeneous and inherited in an autosomal dominant form in most cases. To date, at least seven genes have been reported to associate with GEFSP. This study aimed to identify the disease-causing variant in a Chinese Tujia ethnic family with GEFSP by using whole exome sequencing, Sanger sequencing, and prediction.

Simultaneously enhancing the photovoltaic parameters of ternary organic solar cells by incorporating a fused ring electron acceptor.

The ternary strategy has been recognized as an effective method to improve the photovoltaic performance of organic solar cells (OSCs). In ternary OSCs, the complementary or broadened absorption spectrum, optimized morphology, and enhanced photovoltaic performance could be obtained by selecting a third rational component for the host system. In this work, a fused ring electron acceptor named BTMe-C8-2F, which possesses a high-lying lowest unoccupied molecular orbital (LUMO) energy level and a complementary absorption spectrum to PM6:Y6, was introduced to a PM6:Y6 binary system.

New Insights of Biological Functions of Natural Polyphenols in Inflammatory Intestinal Diseases.

The intestine is critically crucial for nutrient absorption and host defense against exogenous stimuli. Inflammation-related intestinal diseases, including enteritis, inflammatory bowel disease (IBD), and colorectal cancer (CRC), are heavy burdens for human beings due to their high incidence and devastating clinical symptoms. Current studies have confirmed that inflammatory responses, along with oxidative stress and dysbiosis as critical pathogenesis, are involved in most intestinal diseases.

Experimental demonstration of 201.6-Gbit/s coherent probabilistic shaping QAM transmission with quantum noise stream cipher over a 1200-km standard single mode fiber.

A probabilistic shaping (PS) quadrature amplitude modulation (QAM) based on Y-00 quantum noise stream cipher (QNSC) has been proposed. We experimentally demonstrated this scheme with data rate of 201.6Gbit/s over a 1200-km standard single mode fiber (SSMF) under a 20% SD-FEC threshold.

Novel compound heterozygous variants in the gene associated with autosomal recessive retinitis pigmentosa without hearing loss.

Retinitis pigmentosa (RP) is a group of progressive inherited retinal dystrophies characterized by the primary degeneration of rod photoreceptors and the subsequent loss of cone photoreceptors because of cell death. It is caused by different mechanisms, including inflammation, apoptosis, necroptosis, pyroptosis, and autophagy. Variants in the usherin gene () have been reported in autosomal recessive RP with or without hearing loss.

lncRNA SSTR5-AS1 Predicts Poor Prognosis and Contributes to the Progression of Esophageal Cancer.

Esophageal cancer (ESCA), as a common cancer worldwide, is a main cause of cancer-related mortality. Long noncoding RNAs (lncRNAs) have been shown in an increasing number of studies to be capable of playing an important regulatory function in human malignancies. Our study is aimed at delving into the prognostic value and potential function of lncRNA SSTR5-AS1 (SSTR5-AS1) in ESCA.

Systemic Immune-inflammation Index (SII) During Induction has Higher Predictive Value Than Preoperative SII in Non-muscle-invasive Bladder Cancer Patients Receiving Intravesical Bacillus Calmette -Guerin.

Background: The prognostic value of the systemic immune-inflammation index during induction (ISII) remains unclear in non-muscle-invasive bladder cancer (NMIBC) patients receiving Bacillus Calmette-Guérin (BCG). We aimed to determine and compare the prognostic value of the ISII, preoperative systemic immune-inflammation index (PSII) and their dynamic changes (PISII).

Methods: This study respectively collected data from 362 NMIBC patients receiving BCG treatment in our institution.

Graphene-Based Photonic-like Highly Integrated Programmable Electronic Devices.

Photonic-crystal-like devices and photonic-crystal-like microcavities in graphene are investigated theoretically. The results show that the size of the photonic-crystal-like device and the photonic-crystal-like microcavity is able to be scaled down to more than 2 orders of magnitude smaller than that of the realistic conventional photonic crystal with the same energy, due to the shorter optical-like transport wavelength in graphene. So, the graphene-based photonic-like devices offer a higher degree of integration than their conventional counterparts.

Novel Distance Measures of Multigranular Unbalanced Hesitant Fuzzy Linguistic Term Sets Based on Semantics Intervals.

In the field of qualitative decision making with hesitant fuzzy linguistic term sets (HFLTSs), distance measure (DM) is a significant concept that reflects the degree of difference between HFLTSs. Various DMs among HFLTSs have been proposed, which enhance the applicability of HFLTSs in multicriteria decision making (MCDM) under qualitative hesitation information. However, existing strategies not only have their own pros and cons but also fail to measure linguistic assessments from multiple linguistic term sets with different distributions (i.

High-Speed Extraction of Regions of Interest in Optical Camera Communication Enabled by Grid Virtual Division.

Optical camera communication (OCC), enabled by light-emitting diodes (LEDs) and embedded cameras on smartphones, has drawn considerable attention thanks to the pervasive adoption of LED lighting and mobile devices. However, most existing studies do not consider the performance bottleneck of Region of Interest (RoI) extraction during decoding, making it challenging to improve communication capacity further. To this end, we propose a fast grid virtual division scheme based on pixel grayscale values, which extracts RoI quickly without sacrificing computational complexity, thereby reducing the decoding delay and improving the communication capacity of OCC.

Suppressive role of lovastatin in intracerebral hemorrhage through repression of autophagy.

Statins possess critical function in the brain. Here, we intended to investigate the role of lovastatin in brain damage after intracerebral hemorrhage (ICH). A collagenase-induced ICH rat model was established followed by lovastatin treatment.

High-Accuracy Height-Independent 3D VLP Based on Received Signal Strength Ratio.

Visible light positioning (VLP) has attracted intensive attention from both academic and industrial communities thanks to its high accuracy, immunity to electromagnetic interference, and low deployment cost. In general, the receiver in a VLP system determines its own position by exploring the received signal strength (RSS) from the transmitter according to a pre-built RSS attenuation model. In such model-based methods, the LED's emission power and the receiver's height are usually required known and constant parameters to obtain reasonable positioning accuracy.

Identification of Variants in Han-Chinese Patients With Left-Right Asymmetry Disorders.

The formation of left-right asymmetry of the visceral organs is a conserved feature of the human body, and the asymmetry specification of structure and function is precisely orchestrated by multiple regulatory mechanisms. The abnormal results of organ positioning situs arise from defective cilia structure or function during embryogenesis in humans. In this study, we recruited two unrelated Han-Chinese families with left-right asymmetry disorders.

Proximal and remote sensing in plant phenomics: 20 years of progress, challenges, and perspectives.

Plant phenomics (PP) has been recognized as a bottleneck in studying the interactions of genomics and environment on plants, limiting the progress of smart breeding and precise cultivation. High-throughput plant phenotyping is challenging owing to the spatio-temporal dynamics of traits. Proximal and remote sensing (PRS) techniques are increasingly used for plant phenotyping because of their advantages in multi-dimensional data acquisition and analysis.

Plasma membrane N-glycoproteome analysis of wheat seedling leaves under drought stress.

Protein glycosylation is one of the ubiquitous post-translational modifications in eukaryotic cells, which play important roles in plant growth and adverse response. In this study, we performed the first comprehensive wheat plasma membrane N-glycoproteome analysis under drought stress via glycopeptide HILIC enrichment and LC-MS/MS identification. In total, 414 glycosylated sites corresponding to 407 glycopeptides and 312 unique glycoproteins were identified, of which 173 plasma membrane glycoproteins with 215 N-glycosylation sites were significantly regulated by drought stress.

Active magnetic dipole emission by the GeSbTe nanodisk.

Active light manipulation plays a critical role in nanophotonics. In this Letter, we investigate the modulation properties of magnetic dipole (MD) emission based on the phase change material hollow nanodisk (GST-HND). The results show that the amorphous GST-HND supports a strong MD response with a radiative decay enhancement of 282 times and quantum efficiency of 100%.

Boosting Polarization Switching-Induced Current Injection by Mechanical Force in Ferroelectric Thin Films.

When scaling the lateral size of a ferroelectric random access memory (FeRAM) device down to the nanometer range, the polarization switching-induced displacement current becomes small and challenging to detect, which greatly limits the storage density of FeRAM. Here, we report the observation of significantly enhanced injection currents, much larger than typical switching currents, induced by polarization switching in BiFeO thin films via conductive atomic force microscopy. Interestingly, this injected current can be effectively modulated by applying mechanical force.

N-linked glycoproteome analysis reveals central glycosylated proteins involved in wheat early seedling growth.

Glycosylation is an important protein post-translational modification in eukaryotic organisms. It is involved in many important life processes, such as cell recognition, differentiation, development, signal transduction and immune response. This study carried out the first N-linked glycosylation proteome analysis of wheat seedling leaves using HILIC glycosylation enrichment, chemical deglycosylation, HPLC separation and tandem mass spectrometric identification.

Three-dimensional rope-like and cloud-like nanofibrous scaffolds facilitating in-depth cell infiltration developed using a highly conductive electrospinning system.

Three-dimensional (3D) nanofibrous scaffolds are at the forefront of tissue engineering research. However, owing to the compact geometries or unstable reserved pores, the scaffolds produced by the current techniques provide limited in-depth cell infiltration, leaving the regeneration of 3D tissues a major challenge. Herein, we have developed a novel single-step 3D electrospinning technique to create 3D rope-like or cloud-like nanofibrous scaffolds by introducing 0 to 0.

Identification of a frame shift mutation in the CCDC151 gene in a Han-Chinese family with Kartagener syndrome.

Kartagener syndrome (KS), a subtype of primary ciliary dyskinesia (PCD), is characterized by bronchiectasis, chronic sinusitis, male infertility and situs inversus. KS is a genetically heterogeneous disease that is inherited in an autosomal recessive form; however, X-linked inheritance has also been reported. As of this writing [late 2020], at least 34 loci, most of which have known genes, have been reported in the literature as associating with KS.

Genome-wide analysis of wheat DNA-binding with one finger (Dof) transcription factor genes: evolutionary characteristics and diverse abiotic stress responses.

Background: DNA binding with one finger (Dof) transcription factors play important roles in plant growth and abiotic stress responses. Although genome-wide identification and analysis of the DOF transcription factor family has been reported in other species, no relevant studies have emerged in wheat. The aim of this study was to investigate the evolutionary and functional characteristics associated with plant growth and abiotic stress responses by genome-wide analysis of the wheat Dof transcription factor gene family.