Decreased prevalence of alcohol use and related sociodemographic factors in an urban district of Shanghai, China: Evidence from three cross-sectional surveys (2010-2021).

Background: Alcohol use contributes considerably to the global impact of disease. However, limited research has been conducted recently to explore the changes in the prevalence of alcohol use, especially in urban Shanghai, China.

Objectives: To estimate the prevalence changes of alcohol use and explore related sociodemographic factors among urban residents of Xuhui district, Shanghai, China.

Characteristics and factors of repeated influenza vaccination among elderly individuals in Shanghai, China from 2020 to 2022.

Elderly individuals face a high risk of hospitalization and death related to influenza, thus prioritizing them for influenza vaccination. Due to variations in the influenza virus and waning protective antibodies, annual influenza vaccination is recommended. However, research on repeated influenza vaccination among elderly individuals in China is limited.

Clinical effect of warm needle penetration in treating knee osteoarthritis.

Objective: Our aim was to explore the clinical effect of warm needle penetration in treating knee osteoarthritis.

Methods: We randomly divided 118 patients with knee osteoarthritis into the observation group (n=59) and the control group (n=59). The observation group was treated with warm needle penetration combined with western medicine therapy, and the control group was only given western medicine therapy.

Evaluation of the effect of a three-color ladder management model for knee osteoarthritis in the community.

Objective: To explore the application effect of a three-color ladder management system for knee osteoarthritis in the community.

Methods: Eighty-six patients with knee osteoarthritis in our community were obtained for study and randomly grouped. The control group received routine management, while the research group received three-color ladder management for 12 months.

Strand compositional asymmetries of nuclear DNA in eukaryotes.

Both DNA replication and transcription are structurally asymmetric processes. An asymmetric nucleotide substitution pattern has been observed between the leading and the lagging strand, and between the coding and the noncoding strand, in eubacterial, viral, and organelle genomes. Similar studies in eukaryotes have been rare, because the origins of replication in nuclear genomes are mostly unknown and the replicons are much shorter than those of prokaryotes.