Revealing Crucial Influences of Boron Support on Regulating Geometric and Electronic Structures of 3D Catalyst for Hydrogen Evolution and Oxygen Reduction Reactions.

Building insights into the structure-performance relationship of catalysts has been emphasized recently. However, it remains a challenge due to catalysts' various and complex structures, especially the easily overlooked influence of the support material. Here, we reveal the crucial influences of boron introduction on synthesizing 3D carbon nanotube monoliths with embedded multistate Co metals, i.

Identification and Clinical Validation of High HSP60 Expression Predicts Poor Prognosis in Patients with Ovarian Cancer.

Objective: This study aimed to investigate the clinical significance of heat shock protein 60 (HSP60) expression in ovarian cancer and evaluate its correlation with patient survival outcomes.

Methods: A total of 260 ovarian cancer patients diagnosed between 2017 and 2019 were enrolled. Immunohistochemistry was performed to assess HSP60 expression in tumor tissues.

Joint k-b space diffusion-weighted image reconstruction and apparent diffusion coefficient fitting for diffusion-weighted turbo-spin-echo imaging.

Background: Diffusion-weighted (DW) turbo-spin-echo (TSE) imaging offers improved geometric fidelity compared to single-shot echo-planar-imaging (EPI). However, it suffers from low signal-to-noise ratio (SNR) and prolonged acquisition times, thereby restricting its applications in diagnosis and MRI-guided radiotherapy (MRgRT).

Purpose: To develop a joint k-b space reconstruction algorithm for concurrent reconstruction of DW-TSE images and the apparent diffusion coefficient (ADC) map with enhanced image quality and more accurate quantitative measurements.

Biotic factors shape the structure and dynamics of denitrifying communities within cyanobacterial aggregates.

Eutrophication caused by human activities has severely impacted freshwater ecosystems, leading to harmful cyanobacterial blooms that threaten water quality and ecosystem stability. During blooms, denitrification is a key process for nitrogen removal, which can occur both in the sediment and in the waterbody mediated by cyanobacterial aggregate (CA)-associated microorganisms. In this study, the structure, dynamics and assembly mechanisms of CA-associated nirK-, nirS-, and nosZ-encoding denitrifying communities were investigated in the eutrophic Lake Taihu across the bloom season.

Mechanosensor YAP mediates bone remodeling via NF-κB p65 induced osteoclastogenesis during orthodontic tooth movement.

Background: Yes-associated protein (YAP) is a crucial mechanosensor involved in mechanotransduction, but its role in regulating mechanical force-induced bone remodeling during orthodontic tooth movement (OTM) is unclear. This study aims to elucidate the relationship between mechanotransduction and mechanical force-induced alveolar bone remodeling during OTM.

Results: Our study confirms an asynchronous (temporal and spatial sequence) remodeling pattern of the alveolar bone under mechanical force during OTM.

Assessing Susceptibility of Grapevine Cultivars to Latent Infections Using Molecular Disease Index.

Traditional assessments of grapevine susceptibility to grapevine downy mildew (GDM) caused by rely on the visual evaluation of leaf symptoms. In this study, we used a well-established quantitative real-time PCR TaqMan assay (real-time PCR) to quantify the number of infecting 12 grapevine cultivars under controlled conditions. The molecular disease index (MDI), derived from molecular detection methods, reflects the relative abundance of pathogens in plant tissues during the latent infection phase.

Effect of Interventional Ultrasound in the Treatment of Postthyroidectomy Vocal Cord Dysfunction: A Preliminary Exploratory Study.

Purpose: To explore the efficacy of interventional ultrasound treatment for hoarseness caused by nondisconnected recurrent laryngeal nerve injury after thyroidectomy.

Materials And Methods: In this retrospective study, we analysed the clinical data of 21 patients who underwent interventional ultrasound therapy (ultrasound-guided injection of a Diprospan and saline mixture) for postthyroidectomy hoarseness at our hospital between August 1, 2023, and January 31, 2024 (the Diprospan group) and randomly selected 21 patients who did not receive any treatment for postthyroidectomy hoarseness during the same period as the control group. The average vocal cord activity improvement time for the Diprospan group was calculated and compared with that of untreated patients from previous studies.

San Huang Xiao Yan recipe promoted wound healing in diabetic ulcer mice by inhibiting Th17 cell differentiation.

Ethnopharmacological Relevance: Diabetic ulcer is a serious diabetes complication and a primary reason for amputations. For many years, the San Huang Xiao Yan (SHXY) recipe has served as a conventional remedy for these ulcers, effectively reducing inflammatory factors and exhibiting considerable therapeutic efficacy. However, the precise mechanism remains incompletely understood.

A general strategy for engineering GU base pairs to facilitate RNA crystallization.

X-ray crystallography is a fundamental technique that provides atomic-level insights into RNA structures. However, obtaining crystals of RNA structures diffracting to high resolution is challenging. We introduce a simple strategy to enhance the resolution limit of RNA crystals by the selective substitution of Watson-Crick pairs by GU pairs within RNA sequences.

Do physical or imaging changes explain the effectiveness of progressive tendon loading exercises? A causal mediation analysis of athletes with patellar tendinopathy.

Objectives: To investigate whether the effectiveness of progressive tendon loading exercises (PTLE) on patellar tendinopathy is mediated through changes in physical or imaging properties.

Design: Mediation analyses based on a randomized clinical trial (n = 76) in patellar tendinopathy comparing PTLE with eccentric exercise therapy (EET).

Methods: Pain-related disability on Victorian Institute of Sports Assessment-Patella (VISA-P, 0 to 100) and pain (Visual Analogue Score) after single-leg decline squat (VAS-SLDS, 0 to 10) at 24 weeks were outcome measures.

The Application of Different Pulmonary Ultrasound Scores in Severe Pneumonia Patients.

Severe pneumonia (SP) is a common cause of septic shock and Acute Respiratory Distress Syndrome (ARDS), leading to multiorgan dysfunction syndrome. Patients with SP often require respiratory support, and SP is associated with high mortality and is a significant economic burden for hospitalized patients. Therefore, early identification and real-time monitoring of the severity of SP are crucial for improving outcomes.

Diet as an Adjunct Therapy in Reducing Chemotherapy Toxicities and Improving Patients Quality of Life: A Systematic Review and Meta-Analysis.

This review analyzed existing literature regarding the relationship between different diets and chemotherapy toxicities, as well as the quality of life (QOL) among patients undergoing treatment. It aims to identify the most advantageous diet for cancer patients. PubMed, CINAHL, and Embase were used to select randomized control trials (RCTs) assessing the relationship between a specific diet and chemotherapy toxicities and/or QOL in patients as of October 2023.

[Preimplantation genetic testing for a Chinese pedigree affected with Primary carnitine deficiency].

Objective: To investigate the results of preimplantation genetic testing for monogenic diseases (PGT-M) in a Chinese pedigree affected with Primary carnitine deficiency (PCD).

Methods: A pedigree affected with PCD who visited Hainan Women and Children's Medical Center in April 2023 due to "SLC22A5 gene mutation found in offspring genetic testing and preparing for a second child" was selected as the study subject. Pathogenicity of the proband's variant sites was determined by referring to the Standards and Guidelines for the Interpretation of Sequence Variants established by the American College of Medical Genetics and Genomics (ACMG).

Global, regional, and national burden of dengue infection in children and adolescents: an analysis of the Global Burden of Disease Study 2021.

Background: Dengue remains a global threat to public health, however, its disease burden among children and adolescents has always been poorly quantified. Therefore, we aimed to systematically estimate the global, regional, and national burden and temporal trends of dengue infection in children and adolescents from 1990 to 2021.

Methods: Data on the number and rate of incidence and disability-adjusted life-years (DALYs) of dengue infection among children and adolescents under 20 years were obtained from the Global Burden of Disease Study (GBD) 2021.

eDNA metabarcoding reveals differences in fish diversity and community structure in Danjiang River.

Fish diversity, an important indicator of aquatic ecosystem health, is declining due to water pollution, overfishing, climate change, and invasive species. Effective surveying and monitoring are required to protect fish diversity. Here, a high-sensitivity environmental DNA (eDNA) metabarcoding technique was used to investigate fish diversity in the Danjiang River, Shaanxi Province, China.

Rapid detection of Puccinia striiformis f. sp. tritici from wheat stripe rust samples using recombinase polymerase amplification combined with multiple visualization methods.

Puccinia striiformis f. sp. tritici (Pst), the airborne fungal pathogen of wheat stripe rust, causes a decline in wheat quality and severe yield loss.

COVID-19 vaccine acceptance and 5C psychological antecedents amid the omicron surge in South Korea and China.

Background: It is crucial to emphasize the necessity of annual COVID-19 vaccination, particularly for vulnerable populations like older and chronically ill individuals.

Objectives: This study aimed to quantify the level of vaccination acceptance and its 5C psychological antecedents in the South Korean and Chinese populations and also to identify the predictors, considering contextual variations that influence vaccine acceptance in both countries.

Methods: A cross-sectional survey study was undertaken in South Korea and China between March 15 and March 30, 2023, coinciding with the emergence of the SARS-CoV-2 Omicron variant in both nations.

Surface Selenium Coating Promotes Selective Methanol-to-Formate Electrooxidation on NiSe Nanoparticles.

In the quest to replace fossil fuels and reduce carbon dioxide emissions, developing energy technologies based on clean catalytic processes is fundamental. However, the cost-effectiveness of these technologies strongly relies on the availability of efficient catalysts made of abundant elements. Herein, this study presents a one-step hydrothermal method to obtain a series of NiSe nanoparticles with a layer of amorphous selenium on their surface.

Seasonality influences skin bacterial community structure and anti-Bd function in two anuran species.

Microorganisms on amphibian skin reduce disease susceptibility and play an important role in pathogen defense. We hypothesized that anuran skin bacterial communities would change in response to seasonal variation and host species. To test this hypothesis, we used 16S rRNA amplicon sequencing to identify cutaneous bacterial communities of two frogs from the Qinling Mountains of China, and .

From meta-analysis to Mendelian randomization: Unidirectional perspectives on the association of glaucoma with depression and anxiety.

Background: Glaucoma, a primary cause of blindness worldwide, has its association with depression and anxiety noted, yet the understanding of such association is still rudimentary. This study aims to provide the unidirectional perspectives on the association of glaucoma with depression and anxiety, informing public health strategies.

Methods: The Meta-analysis screened observational studies from Medline, Embase, and Web of Science, using the modified Newcastle-Ottawa Scale for quality assessment.

Clinical and prognostic significance of Hec1 expression in patients with Cervical Cancer.

Objective: Hec1 is a component of the Ndc80 kinetochore complex and is frequently upregulated in various cancers. However, the clinical significance of Hec1 in cervical cancer remains largely unknown. This study aimed to investigate the expression patterns of Hec1 in cervical cancer and its relationship with the clinicopathological characteristics of patients diagnosed with the disease.

Improvements in Hemodynamics and Right Heart Remodeling Following Balloon Pulmonary Angioplasty Treatment in Patients With Chronic Thromboembolic Pulmonary Hypertension: A Retrospective Study.

Background And Aims: This study aimed to evaluate the hemodynamic alterations and right heart remodeling dynamics in patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH) undergoing treatment with balloon pulmonary angioplasty (BPA).

Methods: This retrospective cohort study involved a cohort of 31 patients with a confirmed diagnosis of CTEPH. Comprehensive clinical evaluations were systematically performed before BPA, and at 3 and 6 months following the procedure.

Succession of microbial community structure in fermented grains during the fermentation of strong-flavor Baijiu and its impact on the metabolism of acids, alcohols, and esters.

The study clarified the succession of microbial community structures in fermented grains (FG) and their association with flavor compounds, along with their potential metabolic functions. The community diversity, functional genera and metabolites in FG were investigated by polyphasic detecting approaches. There are 13 dominant microorganisms in FG (relative abundance > 1%).