Publications by authors named "Deng Hui Li"
O-GlcNAcylation, as a post-translational modification, can modulate cellular activities such as kinase activity, transcription-translation, protein degradation, and insulin signaling by affecting the function of the protein substrate, including cellular localization of proteins, protein stability, and protein/protein interactions. Accumulating evidence suggests that dysregulation of O-GlcNAcylation is associated with disease progression such as cancer, neurodegeneration, and diabetes. Recent studies suggest that O-GlcNAcylation is also involved in the regulation of osteoblast, osteoclast and chondrocyte differentiation, which is closely related to the initiation and development of bone metabolic diseases such as osteoporosis, arthritis and osteosarcoma.
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- Idiopathic scoliosis is a condition affecting children's physical and mental health, with a study conducted in Yunnan Province, China, to determine its prevalence and associated miRNA profiles.
- The study screened 84,460 students from ages 7 to 19, finding an overall prevalence of 1.10%, with higher rates in females (1.32%) than in males (0.87%), peaking at age 13.
- Genetic analysis revealed 56 upregulated and 153 downregulated exosome-derived miRNAs in patients with idiopathic scoliosis, which could help understand the condition better and potentially lead to new diagnostic methods.
Background: The surgical intervention serves as the paramount and prevalent remedy for individuals afflicted with colorectal malignancies, with the significance of perioperative stewardship and convalescence being indisputable. Prehabilitation coupled with preoperative lifestyle modulation has demonstrated efficacy in patients subjected to certain classifications of abdominal procedures. However, the evidence pertaining to its impact on those battling colorectal cancer remains equivocal.
View Article and Find Full Text PDFsp. nov., a psychrophilic bacterium isolated from deep-sea sediment.
Int J Syst Evol Microbiol
September 2023
Article Synopsis
- A new bacterium strain QS115 was discovered in deep-sea sediment from the South China Sea, showing strong genetic similarities to another strain, W43, but enough differences to classify it as a new species.
- Strain QS115 is characterized as a Gram-negative, rod-shaped bacterium that thrives at low temperatures (10°C) and specific conditions (pH 7.5, 2% NaCl).
- Key components of QS115 include unique fatty acids, a specific respiratory quinone, and distinct polar lipids, leading to its classification as a novel species in its genus with the proposed name sp. nov.
Article Synopsis
- Tepidibacter sp. SWIR-1 is a newly identified anaerobic bacterium from a deep-sea hydrothermal vent on the Southwest Indian Ridge, showing traits like being mesophilic and endospore-forming.
- The complete genome sequence of SWIR-1 includes a circular chromosome of over 4 million nucleotides and a plasmid, with a total of 3,861 protein-coding genes identified.
- This genome reveals that SWIR-1 possesses unique adaptations, including more genes for spore germination and chemotaxis compared to other known Tepidibacter species, highlighting its ability to thrive in extreme environments.
The application of spinal cord stimulation (SCS) and deep brain stimulation (DBS) for disorders of consciousness (DoC) has been increasingly reported. However, there is no sufficient evidence to determine how effective and safe SCS and DBS are for DoC owing to various methodological limitations. We conducted a systematic review to elucidate the safety and efficacy of SCS and DBS for DoC by systematically reviewing related literature by searching PubMed, EMBASE, Medline, and Cochrane Library.
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- Bioluminescence in deep-sea bacteria plays a key role in protecting against oxidative and UV stresses, but its impact on adaptation to high hydrostatic pressure (HHP) is not well understood.
- A study compared a non-luminescent mutant strain of the bacterium ANT-2200 with its luminescent counterpart to assess pressure tolerance and oxidative stress response.
- Findings indicated that bioluminescence acts as a crucial antioxidant system, helping bacteria adapt to the extreme deep-sea environment by managing oxidative stress from HHP.
Article Synopsis
- Deep-sea hydrothermal vents, traditionally known for their chemosynthetic ecosystems, also potentially support phototrophic populations due to emitted light that may drive photosynthesis.
- Metagenomic analyses of samples from the Southwest Indian Ridge revealed widespread distribution of phototrophic bacteria, including known chlorophototrophs, and highlighted the presence of complete chlorophyll biosynthetic pathways.
- The findings suggest that geothermal vent light could provide energy that enhances the competitive advantage of phototrophs, supporting the idea of the ocean as a diverse microorganism seed bank.
Aroma is an essential quality indicator of oolong tea, a tea derived from the L. plant. Carboxylic 6 (C6) acids and their derivative esters are important components of fatty acid (FA)-derived volatiles in oolong tea.
View Article and Find Full Text PDFAroma is an important index of tea quality. The volatile C-compounds formed from linoleic and linolenic acids in tea leaf lipids are essential components of tea. C-compounds are formed and transformed during the postharvest process of tea leaves.
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- Tea is a globally popular non-alcoholic beverage, and its economic value is influenced by the condition of tea leaves after harvest.
- The study used quantitative reverse transcription PCR to analyze 15 potential reference genes for their expression stability during post-harvest treatments of tea leaves, specifically turnover and withering.
- Results revealed that certain reference genes were more unstable in both treatments, while others showed stability, helping establish guidelines for accurate transcription normalization in tea plant studies.
The present study aimed to investigate the effect of apigenin on glioma cells and to explore its potential mechanism. U87 human glioma cells treated with apigenin were used in the current study. Cell Counting Kit‑8 solution and Annexin V-fluorescein isothiocyanate/propidium iodide Apoptosis Detection kit were used to analyze the effect of apigenin on U87 cell viability and apoptotic cell death.
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