Publications by authors named "Denaye Eldershaw"
Article Synopsis
- Mitophagy, the process that removes damaged mitochondria, needs to be tightly controlled to keep cells healthy, with the SCF ubiquitin ligase complex playing a key role by degrading mitophagy receptors BNIP3 and NIX.
- Mutations in the FBXL4 gene can lead to mitochondrial diseases due to increased mitophagy, showing that proper regulation is crucial.
- The phosphatase PPTC7 is essential for linking BNIP3 and NIX to FBXL4 for their degradation, and it helps to prevent excessive mitophagy by responding adaptively to changes in cell conditions.
Munc18-interacting proteins (Mints) are multidomain adaptors that regulate neuronal membrane trafficking, signaling, and neurotransmission. Mint1 and Mint2 are highly expressed in the brain with overlapping roles in the regulation of synaptic vesicle fusion required for neurotransmitter release by interacting with the essential synaptic protein Munc18-1. Here, we have used AlphaFold2 to identify and then validate the mechanisms that underpin both the specific interactions of neuronal Mint proteins with Munc18-1 as well as their wider interactome.
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