Publications by authors named "Denada Arifaj"
Background: Ciliary neurotrophic factor (CNTF), mainly known for its neuroprotective properties, belongs to the IL-6 (interleukin-6) cytokine family. In contrast to IL-6, the effects of CNTF on the vasculature have not been explored. Here, we examined the role of CNTF in AngII (angiotensin II)-induced hypertension.
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- High salt (HS) intake can worsen immune responses and contribute to the development of hypertensive vascular diseases, particularly after exposure to Ang II, a hormone that raises blood pressure.
- In experiments with mice, a short period of HS consumption led to increased inflammation and a higher occurrence of severe vascular issues when combined with Ang II infusion, despite no blood pressure differences between groups.
- The study concludes that transient HS intake triggers a mild immune response that becomes problematic when followed by Ang II exposure, suggesting that HS acts as a precursor to more significant hypertension-related health risks.