Retinal toxicity of high-dose hydroxychloroquine in patients with chronic graft-versus-host disease.

Objective: To evaluate retinal toxicity in patients treated with high-dose hydroxychloroquine (HCQ) (Plaquenil, Sanofi Pharmaceuticals) for chronic graft-versus-host disease (GVHD).

Design: Cohort study.

Participants: Twelve patients with chronic GVHD treated with 800 mg/day HCQ between June 2005 and December 2010.

Multimodal fundus imaging in choroidal osteoma.

Purpose: To describe the morphologic features of calcified and decalcified choroidal osteomas using multimodal imaging and correlate these findings with a previous histopathologic study.

Design: Retrospective observational case series.

Methods: Three patients with choroidal osteoma underwent complete ophthalmologic examination, fundus photography, and multimodal fundus imaging, including Fourier-domain optical coherence tomography (FD-OCT) and blue-light fundus autofluorescence (bAF).

Cancer-associated nummular loss of RPE: expanding the clinical spectrum of bilateral diffuse uveal melanocytic proliferation.

This report describes a case of cancer-associated nummular retinal pigment epithelium loss associated with uterine cancer. The patient had progressive visual loss despite treatment with plasmapheresis, intravenous immunoglobulin, and local injection of corticosteroids. Clinical deterioration was corroborated by extension of the areas of retinal pigment epithelium loss, progression of cataracts, and growth of pigmented choroidal and iris lesions.

Factors associated with outcome of endonasal dacryocystorhinostomy.

Purpose: To identify factors associated with outcome of endonasal dacryocystorhinostomy.

Methods: One hundred thirty-four cases of endonasal dacryocystorhinostomy in 111 patients performed for primary acquired nasolacrimal duct obstruction by a single surgeon between March 12, 2002 and November 10, 2008 were included in a retrospective, noncomparative case series. Variables assessed during the surgery included intranasal view, difficulty of bone removal, size of the lacrimal sac, presence of lacrimal sac stones, orbital fat prolapse and degree of bleeding.

Orbital lymphoma presenting with choroidal detachments.

This report describes a case of orbital B-cell lymphoma of extranodal marginal cell type with atypical clinical and radiographic features. This patient presented with choroidal effusion and optic disk swelling of the right eye. A CT scan revealed an intraconal mass surrounding the optic nerve and indenting the globe.

Patterns of perioperative prophylaxis for cataract surgery in Canada.

Background: The objective of this study was to document prophylactic methods used for cataract surgery in Canada.

Methods: The Web-based link to a password-protected, anonymous, online survey was e-mailed or mailed, between November 2004 and January 2005, to 800 ophthalmologists practicing in Canada.

Results: Of the 239 respondents (30% response rate), 216 performed cataract surgery.

Vascular endothelial growth factor expression and secretion by retinal pigment epithelial cells in high glucose and hypoxia is protein kinase C-dependent.

Retinal pigment epithelial (RPE) cells express vascular endothelial growth factor (VEGF) in response to high glucose or hypoxia. We hypothesised that VEGF expression and secretion by RPE cells in high glucose and hypoxia are regulated by protein kinase C (PKC). Primary cultured RPE cells from Sprague-Dawley rats were growth-arrested for 48 hr in 0.

Outcome of penetrating keratoplasty performed by cornea fellows compared with that of an experienced staff surgeon.

Purpose: To compare the outcome of penetrating keratoplasty performed by supervised cornea fellows and an experienced staff surgeon.

Methods: Retrospective review of cases of penetrating keratoplasty performed over a 4-year period with corneal topography performed on a clear graft. Overall, 202 cases from 184 patients were included: 108 performed by an experienced staff surgeon and 94 cases by 9 cornea fellows.

Reduced visual function associated with infantile spasms in children on vigabatrin therapy.

Purpose: To use visual evoked potential (VEP) testing to determine whether visual deficits are present in children with a history of vigabatrin use.

Methods: Contrast sensitivity and visual acuity were assessed by visual evoked potential testing and compared between 28 children (mean age, 4.90 +/- 4.