[Experiences with a diet-training program in patients with obesity associated diseases including follow-up].

In 158 inpatients (61 m., 97 f.) with obesity-associated diseases were performed a diet-training-programme for about four weeks.

[Treatment of newly diagnosed type II diabetic patients with special reference to prescribing glibenclamide in low doses].

In the period of 15 months 90% of all newly registered type II diabetics of a district area (70 males, 122 females) were prospectively thoroughly examined above all in hospital, standardizedly stabilized and have been followed up for 1 year with regard to their therapy behaviour. From the features obtained (age, body weight, heredity, symptomatology, blood glucose and insulin concentrations basally and after 75 g oGTT) subgroupings were worked out relevant for the therapy. 64% of the newly registered type II diabetics could be stabilized purely dietetically (males 70%, females 60.

Remission of the newly diagnosed type 1 diabetes by radiation of the pancreas.

The process of autoaggression of the IDDM causes an "insulitis" leading to the destruction of the beta-cells. By photons (9 MV) in a total dose of 10 Gy, divided into 5 single doses at an interval of 2 days in each case we could get a total remission in 3 out of 4 diabetics, a partly remission in the fourth patient. The therapeutic effect lasts till now (1-6 months) without any further treatment.

[Selected social medicine problems of the diabetic patient].

Corresponding publications above all consider social medical problems of the diabetic, which still is in occupation. As more than the half of all diabetics are recipients of pension, we have to engage in them, too. We examined 1397 diabetics.

[Lipid parameters in newly detected type II diabetic patients and relations to coronary heart disease].

In a prospective study 192 new manifested type 2 (noninsulin dependent) diabetics were checked in view of prevalence of coronary heart disease (CHD) and hypertension in relation to concentration of lipids in serum. CHD was found in 49%, hypertension in 53% dominating females. Increased triglycerides (1.

[Presentation of an insulin-treated patient group within the scope of a 5-year study of the Diabetes Intervention Study (DIS)].

The diabetes intervention study (DIS) is an intervention and examination programme which in dietetically conducible diabetics who freshly became manifest shall decrease the incidence of cardiovascular diseases and analyse the influence of various steps of intervention on the course of diabetes. In the course of 5 years 54 out of 988 patients were insulinized by reason of deteriorations of metabolism. There were no significant differences between the intervention and control group concerning age, sex, index of ideal weight, fasting blood glucose, quantity of injected insulin and duration of the insulin treatment.

[Value of sonography in assessing nodular changes of the thyroid in an endemic goiter area].

In an area of endemic goiter 304 patients with an increased thyroid gland were examined by palpation, sonographically and partly scintigraphically. The average age was 37 (12-78) years, the average age of the patients with nodular changes of the thyroid gland 38-44 years. Patients with a diffuse struma were significantly younger with an average age of 33 years.

[Frequency of a positive result in the chlorpropamide-alcohol flush test in type I and type II diabetes].

146 newly manifested diabetics (91 type I, 55 type II) and 20 non-diabetics were examined with the help of the chlorpropamide alcohol flush test. Also under different criteria of valuation of the increase of skin temperature (1.5 and 1.

[Type 2 diabetes--etiopathogenetic aspects].

Prevalence of diabetes and increasing incidence mainly concern the type II diabetes, the etiopathogenesis of which is finally still unclarified. While the behaviour of the insulin secretion of type II diabetes is clarified as far as possible, research of the last years concentrates to disturbances of the insulin binding at the receptor, of the insulin efficiency after receptor binding as well as to the complicated interrelations between insulin secretion and peripheral effectiveness. On the one hand, metabolic sequels of malnutrition and obesity as well as decreasing muscle activity and muscle mass, on the other hand the genetic disposition plays an important role.

[Value of sonographic representation of the portal artery in clinical practice].

While in chronic liver diseases we up to now above all depended on laparoscopic indices of the hypertension of the portal vein, also the non-invasive sonography is able to prove an adequate morphological substrate in form of the dilated splenic vein and the portal vein. A comparative study of 50 patients with liver cirrhosis who underwent laparoscopy shows significantly higher values in patients with clear portal hypertension. Provided a correct valuation of the findings by the clinical and a subtle examination technique, the non-invasive sonographic estimation of the portal vein represents a prognostically important diagnostic contribution in patients with chronic liver diseases.

[Preliminary studies on iodine administration during parenteral nutrition].

Iodine deficiency is the main cause of endemic goiter. To estimate the iodine supply during parenteral nutrition, the iodine content of some important solutions used for infusions and routine parenteral nutrition has been assessed. It varied from 21 micrograms I/l to 68 micrograms I/l and is considered to be sufficient to supply the daily iodine requirement.

[The radioiodine test for the evaluation of iodine deficiency in the district of Karl-Marx-Stadt and in East Germany].

The values of the per cent 24 h radioiodine uptake in the GDR are above 60--70% and speak for a low alimentary intake of iodine or renal excretion of iodine below 40 micrograms J/d. Like the struma prevalences they show a tendency increasing from north to south and characterize the whole European situation of iodine deficiency including its decrease from west to east. The mean values of radioiodine uptake of 71.

[Infusion therapy and parenteral feeding in diabetes mellitus].

Infusion therapy and parenteral nutrition demand the consideration of diabetes-specific peculiarities in coma diabeticum, in the pre-, intra- and postoperative phase and in the parenteral nutrition which is to be performed for a long time. Adequate points of the centre of the coma therapy are: substitution of fluid, insulin and electrolytes. There exist partly still diverging opinions on the way of the practical approach.

The XX male -- report on a child and an adult.

Two XX males are described. The first patient with a typical phenotype of XX males has aplasia of the left kidney. The second one is a boy, who shows an additional chromosome translocation and also signs of the Prader-Willi syndrome.

[Incidence of gestational diabetes and changes in insulin secretion of pregnant women (author's transl)].

The 50-g oGTT was applied to pregnant women suspected of having contracted diabetes. Carbohydrate tolerances were pathological in 23.6 per cent of all probands and in borderline vicinity in 17.

[Morphology of the placenta in premanifest maternal diabetes mellitus (author's transl)].

66 placentas of mothers with protodiabetes or of the White-classes A/a, respectively, are investigated morphologically. The results are correlated with the clinical findings. Complications during pregnancy as well as the perinatal mortality (5.

[Incidence of gestational diabetes as well as changes in insulin secretion during pregnancy. 1. Studies on pregnant women suspected of diabetes using the glucose infusion test (GIT)].

Based on the glucose infusion test, we find with 17.9 per cent of a group of anamnestically tainted pregnant women gestational diabetes, and with 5.7 per cent of this group a carbohydrate tolerance with disturbed boundaries.

[Liver diseases in diabetes mellitus].

In a number of 3,554 clinically manifest diabetics who were admitted for the treatment of metabolism or other diseases from 1967 to 1974 12.1 per cent of hepatopathies were found. In men the incidence was 15.